{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:00:12Z","timestamp":1784098812740,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"BC Centre for Disease Control Foundation for Public and Population Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,10,15]]},"abstract":"<jats:p>We report on the rates of cervical intraepithelial neoplasia (CIN) in young women aged 15\u201322 years of age in British Columbia before and after the introduction of an HPV vaccine program. Rates of cervical intraepithelial neoplasia (CIN) 2+ for each age stratum (15\u201322) in the calendar years 2004\u20132012 for the province of British Columbia were obtained from the BC Cancer Agency\u2018s population\u2010based cervical cancer program. Incidence rate ratios (IRR) of CIN2+ were described and compared before and after HPV vaccine program introduction in cohorts born in vaccine eligible years, and in non\u2010vaccine eligible years using piece\u2010wise Poisson regression analysis, and adjusted for age. Between 2004 and 2012, rates of CIN2 and CIN2+ in young women aged 15\u201322 years in the province of British Columbia have decreased overall. After the introduction of the HPV vaccine program, the age adjusted IRR for CIN2+ for young women aged 15\u201317 years decreased significantly from 0.91 (95% CI: 0.86\u20130.98<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) to 0.36 (95% CI: 0.18\u20130.73<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). During the same time period, no similar reduction was found in young women 18\u201322 years. After introduction of HPV vaccine program, IRR for CIN2+ in young women 15\u201317 was significantly reduced for CIN2+ (0.14; 95% CI: 0.04\u2013 0.47;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and CIN2 (0.1; 95% CI: 0.02\u20130.54;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). This ecological analysis shows a significant reduction in CIN2+ lesions in young women aged 15\u201317 years in British Columbia after the introduction of the HPV vaccine in young women despite vaccine uptake levels below 70%.<\/jats:p>","DOI":"10.1002\/ijc.29508","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T22:08:51Z","timestamp":1425679731000},"page":"1931-1937","source":"Crossref","is-referenced-by-count":36,"title":["Reduction in cervical intraepithelial neoplasia in young women in<scp>B<\/scp>ritish<scp>C<\/scp>olumbia after introduction of the<scp>HPV<\/scp>vaccine: An ecological analysis"],"prefix":"10.1002","volume":"137","author":[{"given":"Gina S.","family":"Ogilvie","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of British Columbia Woodward Instructional Resource Centre Vancouver BC Canada"},{"name":"British Columbia Centre for Disease Control Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Naus","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia Woodward Instructional Resource Centre Vancouver BC Canada"},{"name":"British Columbia Centre for Disease Control Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M.","family":"Money","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia Woodward Instructional Resource Centre Vancouver BC Canada"},{"name":"British Columbia Women's Hospital and Health Centre Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon R.","family":"Dobson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia Woodward Instructional Resource Centre Vancouver BC Canada"},{"name":"British Columbia Children's Hospital Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"Miller","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia Woodward Instructional Resource Centre Vancouver BC Canada"},{"name":"British Columbia Cancer Agency Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mel","family":"Krajden","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia Woodward Instructional Resource Centre Vancouver BC Canada"},{"name":"British Columbia Centre for Disease Control Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"van Niekerk","sequence":"additional","affiliation":[{"name":"British Columbia Cancer Agency Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Coldman","sequence":"additional","affiliation":[{"name":"British Columbia Cancer Agency Vancouver BC 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