{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:12:41Z","timestamp":1787969561772,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T00:00:00Z","timestamp":1428710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH (University of Illinois CTSA)","award":["ULITR000050"],"award-info":[{"award-number":["ULITR000050"]}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"crossref","award":["OC110133"],"award-info":[{"award-number":["OC110133"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"crossref","award":["RSG-12-230-01-TBG"],"award-info":[{"award-number":["RSG-12-230-01-TBG"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Nested Teal Pre-Doctoral Scholar Award, UIC Graduate College Medical Research Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>\n                    Ovarian cancer is the fifth leading cause of cancer death among US women. Evidence supports the hypothesis that high\u2010grade serous ovarian cancers (HGSC) may originate in the distal end of the fallopian tube. Although a heterogeneous disease, 96% of HGSC contain mutations in p53. In addition, the \u201cp53 signature,\u201d or overexpression of p53 protein (usually associated with mutation), is a potential precursor lesion of fallopian tube derived HGSC suggesting an essential role for p53 mutation in early serous tumorigenesis. To further clarify p53\u2010mutation dependent effects on cells, murine oviductal epithelial cells (MOE) were stably transfected with a construct encoding for the R273H DNA binding domain mutation in p53, the most common mutation in HGSC. Mutation in p53 was not sufficient to transform MOE cells but did significantly increase cell migration. A similar p53 mutation in murine ovarian surface epithelium (MOSE), another potential progenitor cell for serous cancer, was not sufficient to transform the cells nor change migration suggesting tissue specific effects of p53 mutation. Microarray data confirmed expression changes of pro\u2010migratory genes in p53\n                    <jats:sup>R273H<\/jats:sup>\n                    MOE compared to parental cells, which could be reversed by suppressing Slug expression. Combining p53\n                    <jats:sup>R273H<\/jats:sup>\n                    with KRAS\n                    <jats:sup>G12V<\/jats:sup>\n                    activation caused transformation of MOE into high\u2010grade sarcomatoid carcinoma when xenografted into nude mice. Elucidating the specific role of p53\n                    <jats:sup>R273H<\/jats:sup>\n                    in the fallopian tube will improve understanding of changes at the earliest stage of transformation. This information can help develop chemopreventative strategies to prevent the accumulation of additional mutations and reverse progression of the \u201cp53 signature\u201d thereby, improving survival rates.\n                  <\/jats:p>","DOI":"10.1002\/ijc.29528","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T13:04:29Z","timestamp":1427202269000},"page":"1528-1538","source":"Crossref","is-referenced-by-count":46,"title":["Mutant p53 expression in fallopian tube epithelium drives cell migration"],"prefix":"10.1002","volume":"137","author":[{"given":"Suzanne M.","family":"Quartuccio","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy Center for Pharmaceutical Biotechnology College of Pharmacy University of Illinois at Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subbulakshmi","family":"Karthikeyan","sequence":"additional","affiliation":[{"name":"Department of 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