{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:03:07Z","timestamp":1791820987849,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["P01 CA87969"],"award-info":[{"award-number":["P01 CA87969"]}]},{"name":"NIH","award":["P01 CA55075"],"award-info":[{"award-number":["P01 CA55075"]}]},{"name":"NIH","award":["1UM1 CA167552"],"award-info":[{"award-number":["1UM1 CA167552"]}]},{"name":"NIH","award":["R01 CA137178"],"award-info":[{"award-number":["R01 CA137178"]}]},{"name":"NIH","award":["K24 DK098311"],"award-info":[{"award-number":["K24 DK098311"]}]},{"name":"Entertainment Industry Foundation through the National Colorectal Cancer Research Alliance. A.T.C. is a Damon Runyon Clinical Investigator."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Assessing risk of colorectal adenoma at first\u2010time colonoscopy that are of higher likelihood of developing advanced neoplasia during surveillance could help tailor first\u2010line colorectal cancer screening. We developed prediction models for high\u2010risk colorectal adenoma (at least one adenoma \u22651 cm, or with advanced histology, or \u22653 adenomas) among 4,881 asymptomatic white men and 17,970 women who underwent colonoscopy as their first\u2010time screening for colorectal cancer in two prospective US studies using logistic regressions. C\u2010statistics and Hosmer\u2013Lemeshow tests were used to evaluate discrimination and calibration. Ten\u2010fold cross\u2010validation was used for internal validation. A total of 330 (6.7%) men and 678 (3.8%) women were diagnosed with high\u2010risk adenoma at first\u2010time screening colonoscopy. The model for men included age, family history of colorectal cancer, BMI, smoking, sitting watching TV\/VCR, regular aspirin\/NSAID use, physical activity, and a joint term of multivitamin and alcohol. For women, the model included age, family history of colorectal cancer, BMI, smoking, alcohol, beef\/pork\/lamb as main dish, regular aspirin\/NSAID, calcium, and oral contraceptive use. The C\u2010statistic of the model for men was 0.67 and 0.60 for women (0.64 and 0.57 in cross\u2010validation). Both models calibrated well. The predicted risk of high\u2010risk adenoma for men in the top decile was 15.4% <jats:italic>vs<\/jats:italic>. 1.8% for men in the bottom decile (Odds Ratio [OR]\u2009=\u20099.41), and 6.6% <jats:italic>vs<\/jats:italic>. 2.1% for women (OR\u2009=\u20093.48). In summary, we developed and internally validated an absolute risk assessment tool for high\u2010risk colorectal adenoma among the US population that may provide guidance for first\u2010time colorectal cancer screening.<\/jats:p>","DOI":"10.1002\/ijc.29533","type":"journal-article","created":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T21:47:39Z","timestamp":1427406459000},"page":"1719-1728","source":"Crossref","is-referenced-by-count":25,"title":["Assessing individual risk for high\u2010risk colorectal adenoma at first\u2010time screening colonoscopy"],"prefix":"10.1002","volume":"137","author":[{"given":"Yin","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Nutrition Harvard T.H Chan School of Public Health Boston MA"},{"name":"Department of Epidemiology Harvard T.H. 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