{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:28:23Z","timestamp":1788870503044,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T00:00:00Z","timestamp":1429574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The National Graduate School of Clinical Investigation"},{"name":"Finnish Cancer Research Foundation"},{"name":"Finnish-Norwegian Medical Foundation"},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,10,15]]},"abstract":"<jats:p>\n                    Data on the possible impact of postmenopausal hormone therapy (HT) on the incidence of rare primary fallopian tube carcinoma (PFTC) are scarce. Therefore, we conducted a nationwide case\u2010control study analyzing the association between the use of different HTs and PFTC. All women aged 50 years or older with an incident PFTC (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009360) during 1995\u20132007 were identified from the Finnish Cancer Registry. For each case of PFTC, ten age\u2010 and place of residence\u2010matched controls were selected from the Finnish National Population Register, which also provided information on parity. Data on HT purchases were received from the Prescription Register, and data on hysterectomies and sterilizations from the National Care Register. Controls with a salpingectomy before the PFTC diagnosis of the respective case were excluded. The PFTC risk in relation to different HTs was estimated with a conditional logistic regression model, adjusted for parity, age at last delivery, hysterectomy and sterilization. The use for five years or more of estradiol combined with levonorgestrel\u2010releasing\u2010intrauterine system (odds ratio 2.84, 95% confidence interval 1.10\u20137.38) and sequential estradiol\u2010progestin therapy (EPT; 3.37; 2.23\u20135.08) were both linked with increases in the risk of PFTC, while the risk with use of estradiol\u2010only therapy or continuous EPT was not statistically significantly increased. The OR for the use of tibolone for one year or more was 1.56 (0.55\u20134.41). The use of HT is related to an increased risk of PFTC, particularly when a progestin component is intrauterine or systemic progestin is given in sequential manner.\n                  <\/jats:p>","DOI":"10.1002\/ijc.29549","type":"journal-article","created":{"date-parts":[[2015,4,4]],"date-time":"2015-04-04T03:48:08Z","timestamp":1428119288000},"page":"1947-1952","source":"Crossref","is-referenced-by-count":7,"title":["Postmenopausal hormone therapy\u2013also use of estradiol plus levonorgestrel\u2010intrauterine system is associated with an increased risk of primary fallopian tube carcinoma"],"prefix":"10.1002","volume":"137","author":[{"given":"Virpi","family":"Koskela\u2010Niska","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Helsinki University Hospital FI\u201000029 HUS Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Pukkala","sequence":"additional","affiliation":[{"name":"Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer Research Unioninkatu 20 Helsinki FI\u201000130 Finland"},{"name":"School of Health Sciences FI\u201033014 University of Tampere  Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heli","family":"Lyytinen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Helsinki University Hospital FI\u201000029 HUS Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olavi","family":"Ylikorkala","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Helsinki University Hospital FI\u201000029 HUS Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeusz","family":"Dyba","sequence":"additional","affiliation":[{"name":"Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer Research Unioninkatu 20 Helsinki FI\u201000130 Finland"},{"name":"Public Health\u2013Cancer Policy Support European Commission DG Joint Research Centre, Institute for Health and Consumer Protection Ispra I\u201021027 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2091"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e328011a21f"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70333-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60534-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr446"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2012.663818"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28167"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.03.009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23287"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10970"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.09.018"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22491"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1139"},{"key":"e_1_2_6_15_1","first-page":"120","article-title":"Immunohistochemical findings in primary fallopian tube cancer. 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