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The soluble VEGF decoy receptor (FP3), due to its high affinity to VEGF, is a highly effective and promising strategy to disrupt VEGF signaling pathway. Despite potential advantage and potent therapeutic efficacy, its employment has been limited by very poor <jats:italic>in vivo<\/jats:italic> pharmacokinetic properties. To address this challenge, we designed a novel oncolytic adenovirus (Ad) expressing FP3 (RdB\/FP3). To demonstrate the VEGF\u2010specific nature of RdB\/FP3, replication\u2010incompetent Ad expressing FP3 (dE1\/FP3) was also generated. dE1\/FP3 was highly effective in reducing VEGF expression and functionally elicited an antiangiogeneic effect. Furthermore, RdB\/FP3 exhibited a potent antitumor effect compared with RdB or recombinant FP3. Consistent with these data, RdB\/FP3 was shown to greatly decrease VEGF expression level and vessel density and increase apoptosis in both tumor endothelial and tumor cells, verifying potent suppressive effects of RdB\/FP3 on VEGF\u2010mediated tumor angiogenesis <jats:italic>in vivo<\/jats:italic>. Importantly, the therapeutic mechanism of antitumor effect mediated by RdB\/FP3 is associated with prolonged VEGF silencing efficacy and enhanced oncolysis <jats:italic>via<\/jats:italic> cancer cell\u2010specific replication of oncolytic Ad. Taken together, RdB\/FP3 provides a new promising therapeutic approach in the treatment of cancer and angiogenesis\u2010related diseases.<\/jats:p>","DOI":"10.1002\/ijc.29592","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T03:53:41Z","timestamp":1430884421000},"page":"2253-2269","source":"Crossref","is-referenced-by-count":12,"title":["Potent and long\u2010term antiangiogenic efficacy mediated by <scp>FP<\/scp>3\u2010expressing oncolytic adenovirus"],"prefix":"10.1002","volume":"137","author":[{"given":"Il\u2010Kyu","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Bioengineering College of Engineering Hanyang University 222 Wangsimni\u2010ro Seongdong\u2010Gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyewon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Bioengineering College of Engineering Hanyang University 222 Wangsimni\u2010ro Seongdong\u2010Gu Seoul 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