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In this study, we evaluated if differences in tumor microenvironment would affect the development of cancer cachexia in a murine model, and demonstrated that body weight, adipose tissue and gastrocnemius muscle decreased in tumor\u2010bearing mice. Interestingly, a reduction in heart weight was observed in the intraperitoneal tumor group but not in the subcutaneous group. We evaluated 23 circulating cytokines and members of the TGF\u2010\u03b2 family, and found that levels of IL\u20106, TNF\u2010\u03b1 and activin A increased in both groups of tumor\u2010bearing mice. Eotaxin and G\u2010CSF levels in the intraperitoneal tumor group were higher than in the subcutaneous group. Atrogin 1 and MuRF1 mRNA expressions in the gastrocnemius muscle increased significantly in both groups of tumor\u2010bearing mice, however, in the myocardium, expression of these mRNAs increased in the intraperitoneal group but not in subcutaneous group. Based on these results, we believe that differences in microenvironment where tumor cells develop can affect the progression and phenotype of cancer cachexia through alterations in various circulating factors derived from the tumor microenvironment.<\/jats:p>","DOI":"10.1002\/ijc.29620","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T08:28:41Z","timestamp":1432801721000},"page":"2558-2565","source":"Crossref","is-referenced-by-count":39,"title":["Tumor inoculation site affects the development of cancer cachexia and muscle wasting"],"prefix":"10.1002","volume":"137","author":[{"given":"Tatsuzo","family":"Matsuyama","sequence":"first","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto 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