{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:41:54Z","timestamp":1791265314307,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intramural Research Program of the National Institutes of Health"},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Division of Cancer Epidemiology and Genetics","award":["Z01CP010119"],"award-info":[{"award-number":["Z01CP010119"]}]},{"DOI":"10.13039\/100000066","name":"National Institutes of Environmental Health Sciences","doi-asserted-by":"crossref","award":["Z01ES049030"],"award-info":[{"award-number":["Z01ES049030"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    Metolachlor, a widely used herbicide, is classified as a Group C carcinogen by the U.S. Environmental Protection Agency based on increased liver neoplasms in female rats. Epidemiologic studies of the health effects of metolachlor have been limited. The Agricultural Health Study (AHS) is a prospective cohort study including licensed private and commercial pesticide applicators in Iowa and North Carolina enrolled 1993\u20131997. We evaluated cancer incidence through 2010\/2011 (NC\/IA) for 49,616 applicators, 53% of whom reported ever using metolachlor. We used Poisson regression to evaluate relations between two metrics of metolachlor use (lifetime days, intensity\u2010weighted lifetime days) and cancer incidence. We saw no association between metolachlor use and incidence of all cancers combined (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095,701 with a 5\u2010year lag) or most site\u2010specific cancers. For liver cancer, in analyses restricted to exposed workers, elevations observed at higher categories of use were not statistically significant. However, trends for both lifetime and intensity\u2010weighted lifetime days of metolachor use were positive and statistically significant with an unexposed reference group. A similar pattern was observed for follicular cell lymphoma, but no other lymphoma subtypes. An earlier suggestion of increased lung cancer risk at high levels of metolachlor use in this cohort was not confirmed in this update. This suggestion of an association between metolachlor and liver cancer among pesticide applicators is a novel finding and echoes observation of increased liver neoplasms in some animal studies. However, our findings for both liver cancer and follicular cell lymphoma warrant follow\u2010up to better differentiate effects of metolachlor use from other factors.\n                  <\/jats:p>","DOI":"10.1002\/ijc.29621","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T11:55:30Z","timestamp":1432814130000},"page":"2630-2643","source":"Crossref","is-referenced-by-count":54,"title":["Cancer incidence and metolachlor use in the\n                    <scp>A<\/scp>\n                    gricultural\n                    <scp>H<\/scp>\n                    ealth\n                    <scp>S<\/scp>\n                    tudy: An update"],"prefix":"10.1002","volume":"137","author":[{"given":"Sharon R.","family":"Silver","sequence":"first","affiliation":[{"name":"Division of Surveillance Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Bertke","sequence":"additional","affiliation":[{"name":"Division of Surveillance Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia J.","family":"Hines","sequence":"additional","affiliation":[{"name":"Division of Surveillance Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.R.","family":"Alavanja","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Hoppin","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences North Carolina State University Raleigh NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay H.","family":"Lubin","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Rusiecki","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health Sciences Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale P.","family":"Sandler","sequence":"additional","affiliation":[{"name":"Epidemiology Branch National Institute of Environmental Health Sciences, Research Triangle Park  NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Beane Freeman","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"EPA Reregistration Eligibility Decision (RED) Metolachlor. U.S. Environmental Protection Agency Office of Pesticide Programs (OOP) Prevention Pesticides and Toxic Substances Washington DC 1995. Available at:http:\/\/www.epa.gov\/opp00001\/reregistration\/REDs\/0001.pdf. Accessed July 14 2014."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10590500500235001"},{"issue":"1","key":"e_1_2_6_4_1","first-page":"39","article-title":"Cancer incidence in the Agricultural Health Study","volume":"31","author":"Alavanja MC","year":"2005","journal-title":"Scand J Work Environ Health"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.96104362"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh290"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21758"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph8124608"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901518"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9603-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22635"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/mef011"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jea.7500232"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200201000-00015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jes.2012.79"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jes.2012.31"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-051672"},{"key":"e_1_2_6_18_1","unstructured":"US EPAToxicology Branch Peer Review Committee Memorandum on Metolachlor May 30. Available at:http:\/\/www.epa.gov\/pesticides\/chem_search\/cleared_reviews\/csr_PC\u2010108801_23\u2010Aug\u201085_166.pdfAccessed June 23 2014."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2307\/3434827"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10915810305121"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(99)00019-8"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.11.011"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.20213"},{"key":"e_1_2_6_24_1","unstructured":"US EPA. Second Peer Review of Metolachlor 1991. Available at:http:\/\/www.epa.gov\/pesticides\/chem_search\/cleared_reviews\/csr_PC\u2010108801_17\u2010Apr\u201091_189.pdf. Accessed June 23 2014."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh040"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(97)00163-0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-84551997000300009"},{"key":"e_1_2_6_28_1","unstructured":"US EPAPesticides Industry Sales and Usage: 2006 and 2007 Market Estimates. Available at:http:\/\/www.epa.gov\/opp00001\/pestsales\/07pestsales\/table_of_contents2007.htm. Accessed August 12 2014."},{"key":"e_1_2_6_29_1","unstructured":"US EPAPesticide Industry Sales and Usage: 1994 and 1995 Market Estimates. In: Agency USEP ed. 1997. Available at:http:\/\/www.epa.gov\/opp00001\/pestsales\/95pestsales\/table_of_contents1995.htm. Accessed August 12 2014."},{"key":"e_1_2_6_30_1","volume-title":"Impact of dual magnum on peanut yields in Georgia","author":"Prostko E","year":"2013"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2005.02.002"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.10.015"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.29621","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.29621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:46:28Z","timestamp":1695555988000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.29621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,25]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1002\/ijc.29621"],"URL":"https:\/\/doi.org\/10.1002\/ijc.29621","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,25]]}}}