{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:26:47Z","timestamp":1790713607438,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Institute, National Institutes of Health (NIH)","award":["UM1 CA167551"],"award-info":[{"award-number":["UM1 CA167551"]}]},{"name":"Australasian Colorectal Cancer Family Registry","award":["U01\/U24 CA097735"],"award-info":[{"award-number":["U01\/U24 CA097735"]}]},{"name":"Mayo Clinic Cooperative Family Registry for Colon Cancer Studies","award":["U01\/U24 CA074800"],"award-info":[{"award-number":["U01\/U24 CA074800"]}]},{"name":"Ontario Familial Colorectal Cancer Registry","award":["U01\/U24 CA074783"],"award-info":[{"award-number":["U01\/U24 CA074783"]}]},{"name":"Seattle Colorectal Cancer Family Registry","award":["U01\/U24 CA074794"],"award-info":[{"award-number":["U01\/U24 CA074794"]}]},{"name":"Stanford Consortium Colorectal Cancer Family Registry","award":["U01\/U24 CA074799"],"award-info":[{"award-number":["U01\/U24 CA074799"]}]},{"name":"University of Hawaii Colorectal Cancer Family Registry","award":["U01\/U24 CA074806"],"award-info":[{"award-number":["U01\/U24 CA074806"]}]},{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Servier Staff Scholarship"},{"name":"Victorian Cancer Agency Early Career Seed Grant."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Carriers of germline mutations in DNA mismatch repair (MMR) genes are at increased risk of several cancers including colorectal and gynecologic cancers (Lynch syndrome). There is no substantial evidence that these mutations are associated with an increased risk of cervical cancer. A total of 369 families with at least one carrier of a mutation in a MMR gene (133 <jats:italic>MLH1<\/jats:italic>, 174 <jats:italic>MSH2<\/jats:italic>, 35 <jats:italic>MSH6<\/jats:italic> and 27 <jats:italic>PMS2<\/jats:italic>) were ascertained <jats:italic>via<\/jats:italic> population cancer registries or <jats:italic>via<\/jats:italic> family cancer clinics in Australia, New Zealand, Canada, and USA. Personal and family histories of cancer were obtained from participant interviews. Modified segregation analysis was used to estimate the hazard ratio (incidence rates for carriers relative to those for the general population), and age\u2010specific cumulative risks of cervical cancer for carriers. A total of 65 cases of cervical cancer were reported (including 10 verified by pathology reports). The estimated incidence was 5.6 fold (95% CI: 2.3\u201313.8; <jats:italic>p<\/jats:italic>\u2009=\u20090.001) higher for carriers than for the general population with a corresponding cumulative risk to 80 years of 4.5% (95% CI: 1.9\u201310.7%) compared with 0.8% for the general population. The mean age at diagnosis was 43.1 years (95% CI: 40.0\u201346.2), 3.9 years younger than the reported USA population mean of 47.0 years (<jats:italic>p<\/jats:italic>\u2009=\u20090.02). Women with MMR gene mutations were found to have an increased risk of cervical cancer. Due to limited pathology verification we cannot be certain that a proportion of these cases were not lower uterine segment endometrial cancers involving the endocervix, a recognized cancer of Lynch syndrome.<\/jats:p>","DOI":"10.1002\/ijc.29641","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T23:39:05Z","timestamp":1434411545000},"page":"2757-2761","source":"Crossref","is-referenced-by-count":19,"title":["Lynch syndrome and cervical cancer"],"prefix":"10.1002","volume":"137","author":[{"given":"Yoland C.","family":"Antill","sequence":"first","affiliation":[{"name":"Familial Cancer Centre, Royal Melbourne Hospital, Cabrini Health and Southern Health Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Dowty","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Parkville VIC 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Gallinger","sequence":"additional","affiliation":[{"name":"Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noralane M.","family":"Lindor","sequence":"additional","affiliation":[{"name":"Department of Health Science Research Mayo Clinic Arizona Scottsdale AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Le Marchand","sequence":"additional","affiliation":[{"name":"Epidemiology Program, University of Hawaii Cancer Center Honolulu HI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Hopper","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Parkville VIC Australia"},{"name":"Department of Epidemiology and Institute of Health and Environment School of Public Health Seoul National University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly A.","family":"Newcomb","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle WA"},{"name":"School of Public Health University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Haile","sequence":"additional","affiliation":[{"name":"Division of Oncology Department of Medicine Stanford Cancer Institute, Stanford University  CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Church","sequence":"additional","affiliation":[{"name":"Digestive Diseases Institute, Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Tucker","sequence":"additional","affiliation":[{"name":"Hereditary 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