{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:09:39Z","timestamp":1792271379673,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"GlaxoSmithKline Biologicals S.A.","award":["108288\/108290"],"award-info":[{"award-number":["108288\/108290"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,12,15]]},"abstract":"<jats:p>Cervical glandular neoplasias (CGN) present a challenge for cervical cancer prevention due to their complex histopathology and difficulties in detecting preinvasive stages with current screening practices. Reports of human papillomavirus (HPV) prevalence and type\u2010distribution in CGN vary, providing uncertain evidence to support prophylactic vaccination and HPV screening. This study [108288\/108290] assessed HPV prevalence and type\u2010distribution in women diagnosed with cervical adenocarcinoma <jats:italic>in situ<\/jats:italic> (AIS, <jats:italic>N =<\/jats:italic> 49), adenosquamous carcinoma (ASC, <jats:italic>N =<\/jats:italic> 104), and various adenocarcinoma subtypes (ADC, <jats:italic>N =<\/jats:italic> 461) from 17 European countries, using centralised pathology review and sensitive HPV testing. The highest HPV\u2010positivity rates were observed in AIS (93.9%), ASC (85.6%), and usual\u2010type ADC (90.4%), with much lower rates in rarer ADC subtypes (clear\u2010cell: 27.6%; serous: 30.4%; endometrioid: 12.9%; gastric\u2010type: 0%). The most common HPV types were restricted to HPV16\/18\/45, accounting for 98.3% of all HPV\u2010positive ADC. There were variations in HPV prevalence and ADC type\u2010distribution by country. Age at diagnosis differed by ADC subtype, with usual\u2010type diagnosed in younger women (median: 43 years) compared to rarer subtypes (medians between 57 and 66 years). Moreover, HPV\u2010positive ADC cases were younger than HPV\u2010negative ADC. The six years difference in median age for women with AIS compared to those with usual\u2010type ADC suggests that cytological screening for AIS may be suboptimal. Since the great majority of CGN are HPV16\/18\/45\u2010positive, the incorporation of prophylactic vaccination and HPV testing in cervical cancer screening are important prevention strategies. Our results suggest that special attention should be given to certain rarer ADC subtypes as most appear to be unrelated to HPV.<\/jats:p>","DOI":"10.1002\/ijc.29651","type":"journal-article","created":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T08:55:09Z","timestamp":1434790509000},"page":"2858-2868","source":"Crossref","is-referenced-by-count":143,"title":["Human papillomavirus prevalence and type\u2010distribution in cervical glandular neoplasias: Results from a <scp>E<\/scp>uropean multinational epidemiological study"],"prefix":"10.1002","volume":"137","author":[{"given":"Katsiaryna","family":"Holl","sequence":"first","affiliation":[{"name":"Global Health Economics GSK Vaccines Wavre Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej M.","family":"Nowakowski","sequence":"additional","affiliation":[{"name":"First Department of Oncologic Gynaecology and Gynaecology Medical University of Lublin Poland"},{"name":"Department of Gynaecology and Oncologic Gynaecology Military Institute of Medicine Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ned","family":"Powell","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Genetics, HPV Research Group, Cardiff University School of Medicine Cardiff Wales United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Glenn","family":"McCluggage","sequence":"additional","affiliation":[{"name":"Department of Pathology Belfast Health and Social Care Trust Belfast Northern Ireland United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta C.","family":"Pirog","sequence":"additional","affiliation":[{"name":"Department of Pathology Weill Medical College of Cornell University, New York\u2010Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Collas De Souza","sequence":"additional","affiliation":[{"name":"4Clinics, Biostatistics Paris France (at the time of study)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebren A.","family":"Tjalma","sequence":"additional","affiliation":[{"name":"Multidisciplinary Breast Clinic\u2014Gynecological Oncology Unit Department of Obstetrics and Gynecology Antwerp University Hospital, University of Antwerp Antwerpen Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Rosenlund","sequence":"additional","affiliation":[{"name":"IMS Health Stockholm Sweden"},{"name":"Center for Pharmacoepidemiology, Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Fiander","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Genetics, HPV Research Group, Cardiff University School of Medicine Cardiff Wales United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Castro S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department University Hospital Puerto De Hierro Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileia","family":"Damaskou","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology General Hospital of Patras Achaia Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar A.","family":"Joura","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center Department of Gynecology and Obstetrics Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny","family":"Kirschner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hvidovre University Hospital Hvidovre, Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Koiss","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecologic Oncology St. Stephan Hospital Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"O'Leary","sequence":"additional","affiliation":[{"name":"CERVIVA Research Consortium Funded by the Health Research Board Ireland Based at the Department of Pathology The Coombe Women and Infants University Hospital and Trinity College Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Quint","sequence":"additional","affiliation":[{"name":"DDL Diagnostic Laboratory Rijswijk The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aureli","family":"Torn\u00e9","sequence":"additional","affiliation":[{"name":"Hospital Clinic, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Sheffield Medical School Sheffield England United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Rob","sequence":"additional","affiliation":[{"name":"University Hospital Motol Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Kolomiets","sequence":"additional","affiliation":[{"name":"Institute of Oncology of RAMS Siberian Branch  Tomsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anco","family":"Molijn","sequence":"additional","affiliation":[{"name":"DDL Diagnostic Laboratory Rijswijk The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alevtina","family":"Savicheva","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology DO Ott Research Institute of Obstetrics and Gynaecology St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Shipitsyna","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology DO Ott Research Institute of Obstetrics and Gynaecology St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Rosillon","sequence":"additional","affiliation":[{"name":"Epidemiology Department GlaxoSmithKline Vaccines Wavre Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Jenkins","sequence":"additional","affiliation":[{"name":"DDL Diagnostic Laboratory Rijswijk The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Globocan. Cancer fact sheet. 2012. International Agency for Research on Cancer Lyon France. Available at:http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_cancer.aspx. Last accessed 18 January2015."},{"key":"e_1_2_7_3_1","first-page":"1374","article-title":"Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur","volume":"49","author":"Ferlay J","year":"2013","journal-title":"J Cancer"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.07.018"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0231"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.09.040"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.09.115"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2011.3385"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-553"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25723"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70145-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2011.00891.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31821534b9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annpat.2012.09.230"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64619-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100323"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12012"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.55"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03632.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70230-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27713"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22527"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e31827670fd"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.02.026"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.8.2508-2517.1999"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02580-06"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1480"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800316"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj067"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.05.013"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/106.1.52"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000277"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00552.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.11.024"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2754"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1350"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21139"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200010000-00012"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00280-4"},{"key":"e_1_2_7_40_1","unstructured":"JenkinsD MolijnA PirogK et al. The Complex Relationship of HPV to Cervical Adenocarcinoma \u2010 a cross\u2010sectional survey with LCM\u2010PCR of the relation between HPV tumour histology stage and patient age. In: 29th International Papillomavirus Conference and Clinical Workshop Seattle USA 20\u201325 August2014."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.29651","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.29651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.29651","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.29651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:10:37Z","timestamp":1695514237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.29651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12,15]]}},"alternative-id":["10.1002\/ijc.29651"],"URL":"https:\/\/doi.org\/10.1002\/ijc.29651","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]}}}