{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:31:41Z","timestamp":1761676301234},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T00:00:00Z","timestamp":1437782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mermaid Project (Mermaid II)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,12,15]]},"abstract":"<jats:p>Little research has been conducted on the long\u2010term value of human papillomavirus (HPV) testing after conization. We investigated whether cytology adds to the value of a negative HPV test for long\u2010term prediction of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). In addition, we compared risk of CIN2+ following a negative HPV test in women after conization with that in women from the general population. During 2002\u20132005, 667 women treated for CIN2+ were tested for HPV and cytology 46 months after conization. Only HPV\u2010negative women were included. Women participating in routine screening were age\u2010matched with post\u2010conization HPV\u2010negative women, leaving 13,230 and 477 women, respectively, for analysis. By linkage to the Pathology Data Bank, we identified all cases of CIN2+ by December 2013. The 3\u2010, 5\u2010, 8\u2010 and 10\u2010year risks for CIN2+ were 0.7, 0.9, 2.8 and 5.7% after a negative HPV test and 0.5, 0.8, 2.9 and 6.1% in HPV and cytology\u2010negative women. HPV\u2010negative women in the general population had similar 3\u2010year and 5\u2010year risks of 0.4 and 1.0%; thereafter, they had lower risks of 1.9% at 8 years and 2.7% at 10 years. Our results indicate that HPV testing may be used as a test of cure after conization. In the first 5 years after testing, the risk for CIN2+ of women who were HPV\u2010negative at 34 months after conization was similar to that of HPV\u2010negative women in the general population. After 67 years, however, women who have undergone conization may be at higher risk for CIN2+.<\/jats:p>","DOI":"10.1002\/ijc.29673","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T16:07:21Z","timestamp":1435939641000},"page":"2927-2933","source":"Crossref","is-referenced-by-count":20,"title":["Long\u2010term follow\u2010up of the risk for cervical intraepithelial neoplasia grade 2 or worse in HPV\u2010negative women after conization"],"prefix":"10.1002","volume":"137","author":[{"given":"Camilla F.","family":"Gosvig","sequence":"first","affiliation":[{"name":"Unit of Virus Lifestyle and Genes Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene D.","family":"Huusom","sequence":"additional","affiliation":[{"name":"Unit of Virus Lifestyle and Genes Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus K.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Unit of Statistics Bioinformatics and Registry Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Katrine","family":"Duun\u2010Henriksen","sequence":"additional","affiliation":[{"name":"Unit of Statistics Bioinformatics and Registry Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Unit of Statistics Bioinformatics and Registry Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Iftner","sequence":"additional","affiliation":[{"name":"Experimental Virology Section Universitaetsklinikum Tuebingen Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Svare","sequence":"additional","affiliation":[{"name":"Private Gynecological Clinic Elsinore Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Iftner","sequence":"additional","affiliation":[{"name":"Experimental Virology Section Universitaetsklinikum Tuebingen Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne K.","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Unit of Virus Lifestyle and Genes Danish Cancer Society Research Center Copenhagen Denmark"},{"name":"Department of Gynecology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"CD001318.","article-title":"Surgery for cervical intraepithelial neoplasia","volume":"12","author":"Martin\u2010Hirsch PP","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp089"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.05.016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e31828543c5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70078-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq356"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000056"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.09.002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-013-0320-z"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810393563"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01748.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.01.015"},{"key":"e_1_2_6_15_1","unstructured":"National Health Service Cervical Screening Programmes. 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