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A cluster randomized trial was performed in Bogot\u00e1, Colombia between 2008 and 2012 to evaluate effects of opportunistic breast cancer screening. Thirteen clinics were randomized to an intervention arm and 13 to a control arm. Physicians in intervention clinics were instructed to perform clinical breast examination on all women aged 50\u201369 years attending clinics for non\u2010breast health issues, and then refer them for mammographic screening. Physicians in control clinics were not explicitly instructed to perform breast screening or mammography referrals, but could do so if they thought it indicated (\u201cusual care\u201d). Women were followed for 2\u2010years postrandomization. 7,436 women were enrolled and 7,419 (99.8%) screened in intervention clinics, versus 8,419 enrolled and 1,108 (13.1%) screened in control clinics. Incidence ratios (IR) of early, advanced and all breast cancers were 2.9 (95% CI 1.1\u20139.2), 1.0 (0.3\u20133.5) and 1.9 (0.9\u20134.1) in the first (screening) year of the trial, and the cumulative IR for all breast cancers converged to 1.4 (0.7\u20132.8) by the end of follow\u2010up (Year 2). Eighteen (69.2%) of 26 women with early stage disease had breast conservation surgery (BCS) versus 6 (42.5%) of 14 women with late\u2010stage disease (<jats:italic>p<\/jats:italic>\u2009=\u20090.02). Fifteen (68.2%) of 22 women with breast cancer in the intervention group had BCS versus nine (50.0%) of 18 women in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.34). Well\u2010designed opportunistic clinic\u2010based breast cancer screening programs may be useful for early breast cancer detection in LMICs.<\/jats:p>","DOI":"10.1002\/ijc.29801","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T00:49:24Z","timestamp":1439340564000},"page":"705-713","source":"Crossref","is-referenced-by-count":30,"title":["Increased breast cancer screening and downstaging in <scp>C<\/scp>olombian women: A randomized trial of opportunistic breast\u2010screening"],"prefix":"10.1002","volume":"138","author":[{"given":"Ra\u00fal","family":"Murillo","sequence":"first","affiliation":[{"name":"Instituto Nacional De Cancerolog\u00eda De Colombia Bogot\u00e1 Colombia"},{"name":"Prevention and Implementation Group International Agency for Research on Cancer Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Instituto Nacional De 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