{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:59:33Z","timestamp":1776855573346,"version":"3.51.2"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T00:00:00Z","timestamp":1444003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Institute at the National Institutes of Health","award":["R03 CA171017"],"award-info":[{"award-number":["R03 CA171017"]}]},{"name":"the Swedish Research Council; ALF Project Grant; Region Sk\u00e5ne\/Lund University, Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Thyroid cancer has peak incidence among women of reproductive age, and growth factors, which have procarcinogenic properties, may play an important etiologic role. However, the association between fetal growth rate during a woman's pregnancy and her subsequent risk of thyroid cancer has not been previously examined. We conducted a national cohort study of 1,837,634 mothers who had a total of 3,588,497 live\u2010births in Sweden in 1973\u20132008, followed up for thyroid cancer incidence through 2009. There were 2,202 mothers subsequently diagnosed with thyroid cancer in 36.8 million person\u2010years of follow\u2010up. After adjusting for maternal age, height, weight, smoking, and sociodemographic factors, high fetal growth (birth weight standardized for gestational age and sex) was associated with a subsequent increased risk of thyroid cancer in the mother (incidence rate ratio [IRR] per additional 1 standard deviation, 1.05; 95% CI, 1.01\u20131.09; <jats:italic>p<\/jats:italic>\u2009=\u20090.02). Each 1,000 g increase in the infant's birth weight was associated with a 13% increase in the mother's subsequent risk of thyroid cancer (IRR, 1.13; 95% CI, 1.05\u20131.22; <jats:italic>p<\/jats:italic>\u2009=\u20090.001). These findings appeared to involve both papillary and follicular subtypes, and did not vary significantly by the mother's height, weight or smoking status. In this large national cohort study, high fetal growth during a woman's pregnancy was independently associated with a subsequent increased risk of her developing thyroid cancer. If confirmed, these findings suggest an important role of maternal growth factors in the development of thyroid cancer, and potentially may help facilitate the identification of high\u2010risk subgroups of women.<\/jats:p>","DOI":"10.1002\/ijc.29857","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T23:46:51Z","timestamp":1442533611000},"page":"1085-1093","source":"Crossref","is-referenced-by-count":9,"title":["Fetal growth and subsequent maternal risk of thyroid cancer"],"prefix":"10.1002","volume":"138","author":[{"given":"Casey","family":"Crump","sequence":"first","affiliation":[{"name":"Department of Medicine Stanford University Stanford CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Department of Clinical Sciences, Lund University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiva","family":"Sieh","sequence":"additional","affiliation":[{"name":"Department of Health Research and Policy Stanford University Stanford CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn A.","family":"Winkleby","sequence":"additional","affiliation":[{"name":"Stanford Prevention Research Center Department of Medicine, Stanford University Stanford CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Department of Clinical Sciences, Lund University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2010.05.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/965212"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072502761016511"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2228"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29487"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029177"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60269-X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25066"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24913"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp354"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/mp.54.3.121"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986705774454715"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9914-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.6.1131"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.09.061"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_2_7_18_1","volume-title":"Cancer incidence in five continents","author":"Curado MP","year":"2007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6300(200009\/10)12:5<682::AID-AJHB13>3.0.CO;2-X"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.137737"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061734"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00198-2"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200001000-00011"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03388.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098135"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470316696"},{"key":"e_1_2_7_27_1","volume-title":"Stata Statistical Software: release","author":"StataCorp","year":"2013"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-1375"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.19.2474"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199907000-00017"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20402"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008831802805"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023934518975"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf183"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0158"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1387"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129039-200006000-00005"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-1210-T"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70095-4"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0661"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-006-0023-9"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910490606"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00051679"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi136"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008880429862"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010276"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-14-0053"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28275"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/941568"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9260-4"},{"key":"e_1_2_7_52_1","unstructured":"National Board of Health and Welfare Centre for Epidemiology. The Swedish Medical Birth Registry\u2014a summary of content and quality 2003. Available at:https:\/\/www.socialstyrelsen.se\/Lists\/Artikelkatalog\/Attachments\/10655\/2003-112-3_20031123.pdf."},{"key":"e_1_2_7_53_1","unstructured":"Statistics Sweden. Cancer Incidence in Sweden 2009. Stockholm 2009. Available at:http:\/\/www.socialstyrelsen.se\/Lists\/Artikelkatalog\/Attachments\/18204\/2010-12-17.pdf."},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0022"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.29857","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.29857","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.29857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T02:52:30Z","timestamp":1696387950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.29857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,5]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/ijc.29857"],"URL":"https:\/\/doi.org\/10.1002\/ijc.29857","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,5]]}}}