{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:23:23Z","timestamp":1785842603488,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Danish Cancer Society Research Centre","award":["R20 - A1058-10-S2"],"award-info":[{"award-number":["R20 - A1058-10-S2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,3,15]]},"abstract":"<jats:p>The influence of hormone therapy (HT) on risk for endometrial cancer is still casting which type of HT the clinicians recommend. It is unrevealed if HT has a differential influence on Type I <jats:italic>versus<\/jats:italic> Type II endometrial tumors, and little is known about the influence of, <jats:italic>e.g<\/jats:italic>., different routes of administration and about the influence of tibolone. We followed all Danish women aged 50\u201379 years without previous cancer or hysterectomy (<jats:italic>n<\/jats:italic>\u2009=\u2009914,595) during 1995\u20132009. From the National Prescription Register, we computed HT exposures as time\u2010dependent covariates. Incident endometrial cancers (<jats:italic>n<\/jats:italic>\u2009=\u20096,202) were identified from the National Cancer Registry: 4,972 Type I tumors and 500 Type II tumors. Incidence rate ratios (RRs) and 95% confidence intervals (Cls) were estimated by Poisson regression. Compared with women never on HT, the RR of endometrial cancer was increased with conjugated estrogen: 4.27 (1.92\u20139.52), nonconjugated estrogen: 2.00 (1.87\u20132.13), long cycle combined therapy: 2.89 (2.27\u20133.67), cyclic combined therapy: 2.06 (1.88\u20132.27), tibolone 3.56 (2.94\u20134.32), transdermal estrogen: 2.77 (2.12\u20133.62) and vaginal estrogen: 1.96 (1.77\u20132.17), but not with continuous combined therapy: 1.02 (0.87\u20131.20). In contrast, the risk of Type II tumors appeared decreased with continuous combined therapy: 0.45 (0.20\u20131.01), and estrogen therapy implied a nonsignificantly altered risk of 1.43 (0.85\u20132.41). Our findings support that continuous combined therapy is risk free for Type I tumors, while all other hormone therapies increase risk. In contrast, Type II endometrial cancer was less convincingly associated with hormone use, and continuous combined therapy appeared to decrease the risk.<\/jats:p>","DOI":"10.1002\/ijc.29878","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T16:04:40Z","timestamp":1443629080000},"page":"1506-1515","source":"Crossref","is-referenced-by-count":53,"title":["The influence of hormone therapies on type <scp>I<\/scp> and <scp>II<\/scp> endometrial cancer: A nationwide cohort study"],"prefix":"10.1002","volume":"138","author":[{"given":"Lina S.","family":"M\u00f8rch","sequence":"first","affiliation":[{"name":"The Juliane Marie Centre, Gynecological Clinic, Copenhagen University Hospital Copenhagen Denmark"},{"name":"Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Centre Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne K.","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Unit 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