{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:55:12Z","timestamp":1776128112225,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Research Council under the European Union's Seventh Framework Programme","award":["FP\/2007-2013\/ERC Grant Agreement no 281419 childgrowth2cancer awarded to JLB"],"award-info":[{"award-number":["FP\/2007-2013\/ERC Grant Agreement no 281419 childgrowth2cancer awarded to JLB"]}]},{"name":"European Union's Seventh Framework Program","award":["FP7\/2007-2013, grant agreement no Health-F2-2009-241762 Fatty Liver Inhibition of Progression (FLIP)"],"award-info":[{"award-number":["FP7\/2007-2013, grant agreement no Health-F2-2009-241762 Fatty Liver Inhibition of Progression (FLIP)"]}]},{"name":"New Investigator Grant Award from The Obesity Society (to JLB)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,3,15]]},"abstract":"<jats:p>Whether the prenatal period is critical for the development of adult primary liver cancer (PLC) is sparsely investigated. Recently, attention has been drawn to potential sex\u2010differences in the early origins of adult disease. The association between birth weight and adult PLC, separately in men and women was investigated, using a large cohort of 217,227 children (51% boys), born from 1936 to 1980, from the Copenhagen School Health Records Register, and followed them until 2010 in national registers. Hazard ratios (95% confidence intervals) of PLC (30 years or older) were estimated by Cox regression models stratified by birth cohort. During 5.1 million person\u2010years of follow\u2010up, 185 men and 65 women developed PLC. Sex modified the association between birth weight and adult PLC (<jats:italic>p<\/jats:italic> values for interaction\u2009=\u20090.0005). Compared with a sex\u2010specific reference group of birth weights between 3.25 and 3.75 kg, men with birth weights between 2.00 and 3.25 kg and 3.75\u20135.50 kg, had HRs of 1.48 (1.06\u20132.05) and 0.85 (0.56\u20131.28), respectively. Among women the corresponding HRs were 1.71 (0.90\u20133.29) and 3.43 (1.73\u20136.82). Associations were similar for hepatocellular carcinoma only, across year of birth, and after accounting for diagnoses of alcohol\u2010related disorders, viral hepatitis and biliary cirrhosis. Prenatal exposures influenced the risk of adult PLC, and the effects at the high birth weight levels appeared to be sex\u2010specific. These findings underscore the importance of considering sex\u2010specific mechanisms in the early origins of adult PLC.<\/jats:p>","DOI":"10.1002\/ijc.29900","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T01:49:33Z","timestamp":1445996973000},"page":"1410-1415","source":"Crossref","is-referenced-by-count":14,"title":["Sex\u2010specific associations between birth weight and adult primary liver cancer in a large cohort of <scp>D<\/scp>anish children"],"prefix":"10.1002","volume":"138","author":[{"given":"Esther","family":"Zimmermann","sequence":"first","affiliation":[{"name":"Bispebjerg and Frederiksberg Hospital Institute of Preventive Medicine, The Capital Region Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina L.","family":"Berentzen","sequence":"additional","affiliation":[{"name":"Bispebjerg and Frederiksberg Hospital Institute of Preventive Medicine, The Capital Region Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gamborg","sequence":"additional","affiliation":[{"name":"Bispebjerg and Frederiksberg Hospital Institute of Preventive Medicine, The Capital Region Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorkild I. A.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Bispebjerg and Frederiksberg Hospital Institute of Preventive Medicine, The Capital Region Copenhagen Denmark"},{"name":"The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"},{"name":"MRC Integrative Epidemiology Unit Bristol University Bristol United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Baker","sequence":"additional","affiliation":[{"name":"Bispebjerg and Frederiksberg Hospital Institute of Preventive Medicine, The Capital Region Copenhagen Denmark"},{"name":"The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,24]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Online source:http:\/\/www.who.int\/mediacentre\/factsheets\/fs297\/en\/. 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