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It is therefore important to understand the characteristics of those two distinct cell populations in order to devise treatment strategies which effectively target both cohorts, in particular with respect to cancers, such as glioblastoma. Glioblastoma is the most common primary brain tumour in adults, with a mean patient survival of 12\u201315 months. Importantly, therapeutic improvements have not been forthcoming in the last decade. In this study we compare key features of three pairs of glioblastoma cell populations, each pair consisting of stem cell\u2010like and differentiated cells derived from an individual patient. Our data suggest that while growth rates and expression of key survival\u2010 and apoptosis\u2010mediating proteins are more similar according to differentiation status than genetic similarity, we found no intrinsic differences in response to standard therapeutic interventions, namely exposure to radiation or the alkylating agent temozolomide. Interestingly, we could demonstrate that both stem cell\u2010like and differentiated cells possess the ability to form stem cell\u2010containing tumours in immunocompromised mice and that differentiated cells could potentially be dedifferentiated to potential stem cells. Taken together our data suggest that the differences between tumour stem cell and differentiated cell are particular fluent in glioblastoma.<\/jats:p>","DOI":"10.1002\/ijc.29908","type":"journal-article","created":{"date-parts":[[2015,10,31]],"date-time":"2015-10-31T04:31:35Z","timestamp":1446265895000},"page":"1709-1718","source":"Crossref","is-referenced-by-count":48,"title":["A paired comparison between glioblastoma \u201cstem cells\u201d and differentiated cells"],"prefix":"10.1002","volume":"138","author":[{"given":"Matthias","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine University Medical Center Ulm Ulm Germany"},{"name":"Department of Neurosurgery University Medical Center Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Str\u00f6bele","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine University Medical Center Ulm 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