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Myostatin\/activin inhibition reverses skeletal muscle loss and prolongs survival of tumor\u2010bearing animals. The aim of this investigation was to evaluate the effects of a combination of the soluble myostatin receptor ActRIIB (sActRIIB) and the \u03b2<jats:sub>2<\/jats:sub>\u2010agonist formoterol in the cachectic Lewis lung carcinoma model. The combination of formoterol and sActRIIB was extremely effective in reversing muscle wasting associated with experimental cancer cachexia in mice. Muscle weights from tumor\u2010bearing animals were completely recovered following treatment and this was also reflected in the measured grip strength. This combination increased food intake in both control and tumor\u2010bearing animals. The double treatment also prolonged survival significantly without affecting the weight and growth of the primary tumor. In addition, it significantly reduced the number of metastasis. Concerning the mechanisms for the preservation of muscle mass during cachexia, the effects of formoterol and sActRIIB seemed to be additive, since formoterol reduced the rate of protein degradation (as measured <jats:italic>in vitro<\/jats:italic> as tyrosine release, using incubated isolated individual muscles) while sActRIIB only affected protein synthesis (as measured <jats:italic>in vivo<\/jats:italic> using tritiated phenylalanine). Formoterol also increased the rate of protein synthesis and this seemed to be favored by the presence of sActRIIB. Combining formoterol and sActRIIB seemed to be a very promising treatment for experimental cancer cachexia. Further studies in human patients are necessary and may lead to a highly effective treatment option for muscle wasting associated with cancer.<\/jats:p>","DOI":"10.1002\/ijc.29930","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T23:51:05Z","timestamp":1448322665000},"page":"2021-2029","source":"Crossref","is-referenced-by-count":59,"title":["Complete reversal of muscle wasting in experimental cancer cachexia: Additive effects of activin type <scp>II<\/scp> receptor inhibition and \u03b2\u20102 agonist"],"prefix":"10.1002","volume":"138","author":[{"given":"M\u00edriam","family":"Toledo","sequence":"first","affiliation":[{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia","family":"Busquets","sequence":"additional","affiliation":[{"name":"Cancer Research Group, Departament de 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