{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T09:45:50Z","timestamp":1776246350321,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:00:00Z","timestamp":1452211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,5,15]]},"abstract":"<jats:p>Prediagnostic serum\/plasma concentrations of B\u2010cell activation markers have been associated with future risk of B\u2010cell lymphomas (BCL) in HIV\u2010infected patients and in the general population. Current evidence for the general population is however limited and relies on relatively small numbers of observations, especially for specific histologies. We carried out a nested case\u2010control study, including 218 BCL and 218 matched controls, within two prospective cohorts, to investigate the association between plasma levels of soluble (s)CD27 and sCD30 and future risk of BCL, and main histologic subtypes separately. To expand the evidence further, we performed meta\u2010analyses of the published data on these associations from prospective studies among the general population. Our study revealed a significant relationship between sCD30 concentration and BCL risk (OR\u2009=\u20090.86, 1.53, 1.76, for the 2nd\u20134th quartiles respectively, <jats:italic>p<\/jats:italic> trend\u2009=\u20090.01). Similar increased risks were observed for diffuse large B\u2010cell lymphoma and follicular lymphoma. Analyses of sCD27 blood concentrations did not show significant associations with BCL, (OR\u2009=\u20090.90, 1.26, 1.65 for the 2nd\u20134th quartiles, respectively, <jats:italic>p<\/jats:italic> trend\u2009=\u20090.17), but significant associations were observed for chronic lymphocytic leukaemia and for the group of \u201cother BCL\u201d subtypes. Our findings involving sCD30 were confirmed within our meta\u2010analyses of five prospective cohorts, while results were more heterogeneous for sCD27 with the exception of CLL which was found consistently in all studies. Data to date suggest that chronic B\u2010cell stimulation might be an important mechanism involved in B\u2010cell lymphomagenesis both in HIV\u2010infected and in the general population.<\/jats:p>","DOI":"10.1002\/ijc.29969","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T02:45:15Z","timestamp":1450493115000},"page":"2357-2367","source":"Crossref","is-referenced-by-count":22,"title":["Soluble B\u2010cell activation marker of sCD27 and sCD30 and future risk of B\u2010cell lymphomas: A nested case\u2010control study and meta\u2010analyses"],"prefix":"10.1002","volume":"138","author":[{"given":"Fatemeh Saberi","family":"Hosnijeh","sequence":"first","affiliation":[{"name":"Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University Utrecht The Netherlands"},{"name":"Department of Internal Medicine Erasmus University Medical Center Rotterdam The 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