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The risk of detecting CIN associated with the same HPV type as the reference infection was analysed using Kaplan\u2013Meier and multivariable Cox models. Infections were categorised depending upon persistence as 6\u2010month persistent infection (6MPI) or infection of any duration. The 4\u2010year interim analysis included 2,838 women, of whom 1,073 (37.8%) experienced 2,615 infections of any duration and 708 (24.9%) experienced 1,130 6MPIs. Infection with oncogenic HPV types significantly increased the risk of detecting CIN grade 2 or greater (CIN2+) versus non\u2010oncogenic types. For 6MPI, the highest risk was associated with HPV\u201033 (hazard ratio [HR]: 31.9 [8.3\u2013122.2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001]). The next highest risk was with HPV\u201016 (21.1 [6.3\u201370.0], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Similar findings were seen for infections of any duration. Significant risk was also observed for HPV\u201018, HPV\u201031, and HPV\u201045. Concomitant HPV infection or CIN grade 1 or greater associated with a different oncogenic HPV type increased risk. Most women (79.3%) with an HPV infection at baseline cleared detectable infections of any duration, and 69.9% cleared a 6MPI. The risk of progression of HPV infection to CIN2+ in women &gt;25 years in this study was similar to that in women 15\u201325 years in PATRICIA.<\/jats:p>","DOI":"10.1002\/ijc.29971","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T15:54:43Z","timestamp":1450540483000},"page":"2428-2438","source":"Crossref","is-referenced-by-count":104,"title":["Progression of HPV infection to detectable cervical lesions or clearance in adult women: Analysis of the control arm of the VIVIANE study"],"prefix":"10.1002","volume":"138","author":[{"given":"S.","family":"Rachel Skinner","sequence":"first","affiliation":[{"name":"Vaccines Trials Group, Telethon Institute for Child Health Research, Perth, WA and Sydney University Discipline of Paediatrics and Child Health, Children's Hospital Westmead Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosette 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