{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:27:13Z","timestamp":1791311233959,"version":"4.3.1"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,5,15]]},"abstract":"<jats:p>Breast cancer is the most frequently diagnosed cancer among women worldwide. Breast cancer risk factors have been widely explored individually; however, little is known about their combined impact. We included 67,634 women from the French E3N prospective cohort, aged 42\u201372 at baseline. During a 15\u2010year follow\u2010up period, 497 premenopausal and 3,138 postmenopausal invasive breast cancer cases were diagnosed. Population\u2010attributable fractions (PAFs) were used to estimate cases proportions attributable to risk factors under hypothetical scenarios of lowest exposure. We examined overall premenopausal and postmenopausal invasive breast cancers and tumour subtypes (ER status and HER2 expression). Premenopausal breast cancer was not significantly attributable to non\u2010behavioral (61.2%, \u221215.5 to 91.88%) nor to behavioral (39.9%, \u221271.0 to 93.9%) factors, contrary to postmenopausal breast cancer (41.9%, 4.5 to 68.7% and 53.5%, 12.8 to 78.7%, respectively). Individually, the highest statistically significant PAFs were obtained in premenopause for birth weight (33.6%, 5.7 to 56.6%) and age at menarche (19.8%, 5.2 to 33.6%) for non\u2010behavioral factors and in postmenopause for history of benign breast diseases (14.9%, 11.6 to 18.0%) and age at menarche (9.7%, 3.9 to 15.5%) for non\u2010behavioral factors and for body shape at menarche (17.1%, 9.7 to 24.3%), use of hormone replacement therapy (14.5%, 9.2 to 19.6%), dietary pattern (10.1%, 2.6 to 17.4%) and alcohol consumption (5.6%, 1.9 to 9.3%) for behavioral factors. These proportions were higher for ER+, HER2\u2212 and ER+\/HER2\u2212 postmenopausal breast cancers. Our data support the hypothesis that in postmenopause, never starting unhealthy behaviors can reduce the number of diagnosed breast cancers.<\/jats:p>","DOI":"10.1002\/ijc.29987","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T02:28:28Z","timestamp":1452652108000},"page":"2415-2427","source":"Crossref","is-referenced-by-count":46,"title":["Proportion of premenopausal and postmenopausal breast cancers attributable to known risk factors: Estimates from the <scp>E3N\u2010EPIC<\/scp> cohort"],"prefix":"10.1002","volume":"138","author":[{"given":"Laureen","family":"Dartois","sequence":"first","affiliation":[{"name":"Inserm (Institut National De La Sant\u00e9 Et De La Recherche M\u00e9dical), Centre for Research in Epidemiology and Population Health (CESP) U1018, Team 9 Villejuif F\u201094805 France"},{"name":"Universit\u00e9 Paris\u2010Sud UMRS 1018 Villejuif F\u201094805 France"},{"name":"Gustave Roussy Villejuif F\u201094805 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Fagherazzi","sequence":"additional","affiliation":[{"name":"Inserm (Institut National De La Sant\u00e9 Et De La Recherche M\u00e9dical), Centre for Research in Epidemiology and Population Health (CESP) U1018, Team 9 Villejuif F\u201094805 France"},{"name":"Universit\u00e9 Paris\u2010Sud UMRS 1018 Villejuif F\u201094805 France"},{"name":"Gustave Roussy Villejuif F\u201094805 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Baglietto","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Centre, Cancer Council of Victoria Melbourne, Victoria Australia"},{"name":"Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health University of Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Boutron\u2010Ruault","sequence":"additional","affiliation":[{"name":"Inserm (Institut National De La Sant\u00e9 Et De La Recherche M\u00e9dical), Centre for Research in Epidemiology and Population Health (CESP) U1018, Team 9 Villejuif F\u201094805 France"},{"name":"Universit\u00e9 Paris\u2010Sud UMRS 1018 Villejuif F\u201094805 France"},{"name":"Gustave Roussy Villejuif F\u201094805 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzette","family":"Delaloge","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Gustave Roussy Villejuif F\u201094805 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Mesrine","sequence":"additional","affiliation":[{"name":"Inserm (Institut National De La Sant\u00e9 Et De La Recherche M\u00e9dical), Centre for Research in Epidemiology and Population Health (CESP) U1018, Team 9 Villejuif F\u201094805 France"},{"name":"Universit\u00e9 Paris\u2010Sud UMRS 1018 Villejuif F\u201094805 France"},{"name":"Gustave Roussy Villejuif F\u201094805 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Clavel\u2010Chapelon","sequence":"additional","affiliation":[{"name":"Inserm (Institut National De La Sant\u00e9 Et De La Recherche M\u00e9dical), Centre for Research in Epidemiology and Population Health (CESP) U1018, Team 9 Villejuif F\u201094805 France"},{"name":"Universit\u00e9 Paris\u2010Sud UMRS 1018 Villejuif F\u201094805 France"},{"name":"Gustave Roussy Villejuif F\u201094805 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"FerlayJ SoerjomataramI ErvikM et al. 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