{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:05:42Z","timestamp":1740103542662,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T00:00:00Z","timestamp":1456358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Cancer Society (H.E.)","award":["CAN 2010\/225 and CAN 2011\/883"],"award-info":[{"award-number":["CAN 2010\/225 and CAN 2011\/883"]}]},{"name":"Radiumhemmet Research","award":["124083 and 124092"],"award-info":[{"award-number":["124083 and 124092"]}]},{"name":"The Sigurd and Elsa Golijes Memorial Foundation","award":["LA2012-0112"],"award-info":[{"award-number":["LA2012-0112"]}]},{"name":"The Stockholm County Council","award":["20100032"],"award-info":[{"award-number":["20100032"]}]},{"name":"Swedish Cancer Society (T.A.)","award":["140696"],"award-info":[{"award-number":["140696"]}]},{"DOI":"10.13039\/501100001862","name":"The Swedish Research Council","doi-asserted-by":"crossref","award":["521-2011-3205"],"award-info":[{"award-number":["521-2011-3205"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish E-Science Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,6,15]]},"abstract":"<jats:p>The survival in cutaneous malignant melanoma (CMM) is highly dependent on the stage of the disease. Stage III\u2013IV CMM patients are at high risk of relapse with a heterogeneous outcome, but not all experience excess mortality due to their disease. This group is referred to as the cure proportion representing the proportion of patients who experience the same mortality rate as the general population. The aim of this study was to estimate the cure proportion of patients diagnosed with Stage III\u2013IV CMM in Sweden. From the population\u2010based Swedish Melanoma Register, we included 856 patients diagnosed with primary Stage III\u2013IV CMM, 1990\u20132007, followed\u2010up through 2013. We used flexible parametric cure models to estimate cure proportions and median survival times (MSTs) of uncured by sex, age, tumor site, ulceration status (in Stage III patients) and disease stage. The standardized (over sex, age and site) cure proportion was lower in Stage IV CMMs (0.15, 95% CI 0.09\u20130.22) than non\u2010ulcerated Stage III CMMs (0.48, 95% CI 0.41\u20130.55) with a statistically significant difference of 0.33 (95% CI\u2009=\u20090.24\u20130.41). Ulcerated Stage III CMMs had a cure proportion of 0.27 (95% CI 0.21\u20130.32) with a statistically significant difference compared to non\u2010ulcerated Stage III CMMs (difference 0.21; 95% CI\u2009=\u20090.13\u20130.30). The standardized MST of uncured was approximately 9\u201310 months longer for non\u2010ulcerated versus ulcerated Stage III CMMs. We could demonstrate a significantly better outcome in patients diagnosed with non\u2010ulcerated Stage III CMMs compared to ulcerated Stage III CMMs and Stage IV disease after adjusting for age, sex and tumor site.<\/jats:p>","DOI":"10.1002\/ijc.30023","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T23:28:50Z","timestamp":1453937330000},"page":"2829-2836","source":"Crossref","is-referenced-by-count":8,"title":["The proportion cured of patients diagnosed with Stage III\u2013IV cutaneous malignant melanoma in <scp>S<\/scp>weden 1990\u20132007: A population\u2010based study"],"prefix":"10.1002","volume":"138","author":[{"given":"Hanna","family":"Eriksson","sequence":"first","affiliation":[{"name":"Department of Oncology\u2010Pathology, Karolinska Institutet, and Deptartment of Oncology Karolinska University Hospital SE\u201017176 Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Lyth","sequence":"additional","affiliation":[{"name":"Unit of Research and Development in Local Health Care, County of \u00d6sterg\u00f6tland Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese M\u2010L","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13483"},{"key":"e_1_2_8_3_1","unstructured":"FerlayJ SoerjomataramI ErvikM et al. 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