{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:44:30Z","timestamp":1768293870172,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T00:00:00Z","timestamp":1457740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Academy of Finland consortium (project \u201cTumour Microenvironment & Metastasis in Castration-Resistant Prostate Cancer)","award":["267326"],"award-info":[{"award-number":["267326"]}]},{"DOI":"10.13039\/501100009420","name":"Hospital District of Southwest Finland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009420","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Fibroblast growth factor homologous factors (FHFs) belong to the fibroblast growth factor (FGF) superfamily, which plays an important role in prostate cancer (PCa). Mining of public database suggests that FGF13 (FHF2) mRNA expression is altered in over 30% of PCa cases. This study examined the FGF13 expression pattern in human PCa specimens and evaluated its potential as a biomarker for patient outcome after radical prostatectomy (RP). Immunohistochemistry (IHC) showed that FGF13 was detectable in the majority of human PCa samples, and FGF13 IHC scores were higher in high\u2010grade prostatic intraepithelial neoplasia, in primary PCa and in metastatic PCa than in benign prostatic tissue. There was a significant association between high cytoplasmic FGF13 staining and a risk of biochemical recurrence (BCR) after RP. This was also evident in the intermediate to high\u2010risk patient groups. In contrast, positive nuclear FGF13 staining along with low cytoplasmic FGF13 group showed a decreased BCR risk. Multivariate regression analysis indicated that high cytoplasmic FGF13 staining was associated with BCR and that this could serve as an independent prognostic marker in PCa. Several PCa cell lines showed increased FGF13 expression at the mRNA and protein levels compared to the immortalized prostate epithelial cell line PNT1a. Analysis of co\u2010labeled cells suggested a possible interaction of FGF13 with \u03b1\u2010tubulin and the voltage\u2010gated sodium channel proteins (Na<jats:sub>V<\/jats:sub>s\/VGSCs). Our data indicate that, for PCa patients after RP, FGF13 serves as a potential novel prognostic marker that improves prediction of BCR\u2010free survival, in particular if combined with other clinical parameters.<\/jats:p>","DOI":"10.1002\/ijc.30048","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T15:26:51Z","timestamp":1455809211000},"page":"140-152","source":"Crossref","is-referenced-by-count":23,"title":["Increased expression of fibroblast growth factor 13 in prostate cancer is associated with shortened time to biochemical recurrence after radical prostatectomy"],"prefix":"10.1002","volume":"139","author":[{"given":"Lan","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Anatomy Institute of Biomedicine, University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervi","family":"Toriseva","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and 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