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Since angiogenesis is necessary for solid cancer growth and spread, we hypothesized that women with a history of HDP might have a reduced risk of solid cancers (cancers other than lymphomas, hematologic cancers and nonmelanoma skin cancers) later in life. In a register\u2010based cohort study of 1.08 million women giving birth at least once between 1978 and 2011, we used Cox regression to estimate hazard ratios (HRs) comparing solid cancer rates for women with and without a history of HDP. In this cohort, 68,236 women (6.3%) had \u22651 pregnancy complicated by HDP and 42,236 women (3.9%) developed solid tumors during follow\u2010up. A history of HDP was not associated with a clinically meaningful reduction in the overall rate of solid cancer (HR 0.96, 95% confidence interval 0.92\u20131.00), regardless of HDP severity or time since HDP, nor was there a general tendency toward reduced solid cancer rates across organ sites. A history of HDP was only significantly associated with decreased rates of breast and lung cancers and with increased rates of endometrial and urinary tract cancers. Overall, our results do not support the hypothesis that women with a history of HDP have a reduced overall risk of solid cancer due to a persistent post\u2010HDP antiangiogenic state or an innate tendency toward antiangiogenesis. Observed associations with specific cancers may instead be due to other pregnancy\u2010related mechanisms or to residual\/unmeasured confounding.<\/jats:p>","DOI":"10.1002\/ijc.30065","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T10:43:09Z","timestamp":1456483389000},"page":"58-64","source":"Crossref","is-referenced-by-count":13,"title":["Hypertensive disorders of pregnancy and subsequent risk of solid cancer\u2014A nationwide cohort study"],"prefix":"10.1002","volume":"139","author":[{"given":"Ida","family":"Behrens","sequence":"first","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saima","family":"Basit","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Jensen","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob Alexander","family":"Lykke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Rigshospitalet (Copenhagen University Hospital) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars Peter","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Autoimmunology and Biomarkers Statens Serum Institut Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Wohlfahrt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne K.","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center Copenhagen Denmark"},{"name":"Department of Gynaecology Rigshospitalet, University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads","family":"Melbye","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"},{"name":"Department of Medicine Stanford University School of Medicine Stanford CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather Allison","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1122","article-title":"Hypertension in pregnancy. 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