{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:13:35Z","timestamp":1789420415802,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T00:00:00Z","timestamp":1459900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["BC100414"],"award-info":[{"award-number":["BC100414"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["BC972772"],"award-info":[{"award-number":["BC972772"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,7,15]]},"abstract":"<jats:p>Vehicular traffic polycyclic aromatic hydrocarbons (PAHs) have been associated with breast cancer incidence in epidemiologic studies, including our own. Because PAHs damage DNA by forming adducts and oxidative lesions, genetic polymorphisms that alter DNA repair capacity may modify associations between PAH\u2010related exposures and breast cancer risk. Our goal was to examine the association between vehicular traffic exposure and breast cancer incidence within strata of a panel of nine biologically plausible nucleotide excision repair (NER) and base excision repair (BER) genotypes. Residential histories of 1,508 cases and 1,556 controls were assessed in the Long Island Breast Cancer Study Project between 1996 and 1997 and used to reconstruct residential traffic exposures to benzo[a]pyrene, as a proxy for traffic\u2010related PAHs. Likelihood ratio tests from adjusted unconditional logistic regression models were used to assess multiplicative interactions. A gene\u2010traffic interaction was evident (<jats:italic>p<\/jats:italic>\u2009=\u20090.04) for <jats:italic>ERCC2<\/jats:italic> (Lys751); when comparing the upper and lower tertiles of 1995 traffic exposure estimates, the odds ratio (95% confidence interval) was 2.09 (1.13, 3.90) among women with homozygous variant alleles. Corresponding odds ratios for 1960\u20131990 traffic were also elevated nearly 2\u20133\u2010fold for <jats:italic>XRCC1<\/jats:italic>(Arg194Trp), <jats:italic>XRCC1<\/jats:italic>(Arg399Gln) and <jats:italic>OGG1<\/jats:italic>(Ser326Cys), but formal multiplicative interaction was not evident. When DNA repair variants for <jats:italic>ERCC2<\/jats:italic>, <jats:italic>XRCC1<\/jats:italic> and <jats:italic>OGG1<\/jats:italic> were combined, among women with 4\u20136 variants, the odds ratios were 2.32 (1.22, 4.49) for 1995 traffic and 2.96 (1.06, 8.21) for 1960\u20131990 traffic. Our study is first to report positive associations between traffic\u2010related PAH exposure and breast cancer incidence among women with select biologically plausible DNA repair genotypes.<\/jats:p>","DOI":"10.1002\/ijc.30079","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T08:46:18Z","timestamp":1457253978000},"page":"310-321","source":"Crossref","is-referenced-by-count":27,"title":["Polymorphisms in DNA repair genes, traffic\u2010related polycyclic aromatic hydrocarbon exposure and breast cancer incidence"],"prefix":"10.1002","volume":"139","author":[{"given":"Irina","family":"Mordukhovich","sequence":"first","affiliation":[{"name":"Department of Epidemiology Lambertville NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Beyea","sequence":"additional","affiliation":[{"name":"Consulting in the Public Interest Lambertville NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy H.","family":"Herring","sequence":"additional","affiliation":[{"name":"Biostatistics, University of North Carolina Chapel Hill NC"},{"name":"Carolina Population Center, University of North Carolina Chapel Hill NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Hatch","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Stellman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Teitelbaum","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Mount Sinai School of Medicine New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Lambertville NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Millikan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Lambertville NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Lambertville NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumitra","family":"Shantakumar","sequence":"additional","affiliation":[{"name":"Glaxo\u2010Smith Kline, Inc  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Steck","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Arnold School of Public Health, University of South Carolina  South Carolina CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred I.","family":"Neugut","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Columbia University New York NY"},{"name":"Departments of Medicine Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Pavel","family":"Rossner","sequence":"additional","affiliation":[{"name":"Environmental Health Sciences Columbia University New York NY"},{"name":"Laboratory of Genetic Ecotoxicology Institute of Experimental Medicine as CR Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina M.","family":"Santella","sequence":"additional","affiliation":[{"name":"Environmental Health Sciences Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilie D.","family":"Gammon","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Lambertville NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,6]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Breast cancer facts and figures","author":"American Cancer Society","year":"2011"},{"key":"e_1_2_7_3_1","volume-title":"Global cancer facts & figures","author":"American Cancer Society.","year":"2015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.02110s3451"},{"key":"e_1_2_7_5_1","volume-title":"Some non\u2010heterocyclic polycyclic aromatic hydrocarbons and some related exposures. 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