{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:51:27Z","timestamp":1775807487560,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,8,15]]},"abstract":"<jats:p>The relationship of folic acid supplementation with the risk of cancer remains inconclusive. We aimed to evaluate the effects of folic acid supplementation on cancer incidence among adults with hypertension without history of stroke or myocardial infarction (MI) in the China Stroke Primary Prevention Trial (CSPPT). A total of 20,702 hypertensive adults without history of stroke or MI, stratified by <jats:italic>MTHFR<\/jats:italic> C677T genotypes(CC, CT and TT), were randomly assigned to receive double\u2010blind daily treatment with a single pill containing 10 mg enalapril and 0.8 mg folic acid(<jats:italic>n<\/jats:italic>\u2009=\u200910,348) or a pill containing 10 mg enalapril alone(<jats:italic>n<\/jats:italic>\u2009=\u200910,354). During a median treatment duration of 4.5 years, cancer occurred in 116 participants(1.12%) in the enalapril\u2010folic acid group versus 116 participants(1.12%) in the enalapril group (HR, 1.00; 95%CI, 0.77\u20131.29). There was also no significant difference in the HRs for specific types of cancer(esophageal, gastric, breast, lung, colorectal, head and neck, liver and gynecologic cancer or lymphoma) or cancer mortality(HR, 1.05; 95%CI, 0.69\u20131.58). For participants not receiving folic acid treatment (enalapril only group), <jats:italic>MTHFR<\/jats:italic> 677 TT genotype was an independent predictor of total cancer risk compared to CC genotype (HR, 1.86; 95%CI, 1.07\u20133.22). Consistently, a beneficial effect was observed in participants with <jats:italic>MTHFR<\/jats:italic> TT genotype and low folate levels (&lt;9.0 ng\/mL; HR, 0.47; 95%CI, 0.24\u20130.94). There is no evidence that 0.8 mg daily folic acid supplementation can increase the risk of cancer incidence among adults with hypertension without history of stroke or MI in China. Our data suggest a protective effect in participants with <jats:italic>MTHFR<\/jats:italic> TT genotype and low folate levels.<\/jats:p>","DOI":"10.1002\/ijc.30094","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T07:06:45Z","timestamp":1458371205000},"page":"837-847","source":"Crossref","is-referenced-by-count":27,"title":["Effect of folic acid supplementation on cancer risk among adults with hypertension in <scp>C<\/scp>hina: A randomized clinical trial"],"prefix":"10.1002","volume":"141","author":[{"given":"Xianhui","family":"Qin","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Kidney Disease; State Key Laboratory for Organ Failure Research; Renal Division Nanfang Hospital, Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Shen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research 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