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We identified a total of 1,409 women with Turner syndrome and 1,085 men with Klinefelter syndrome from the Swedish Hospital Discharge and Outpatient Register. These individuals were further linked to the Swedish Cancer Register to examine the standardized incidence ratios (SIRs) of cancer using the general population without Turner and Klinefelter syndromes as reference. The overall risk of cancer was 1.34 for women with Turner syndrome; it was increased only for solid tumors. For a specific type of tumor, the risk of melanoma and central nervous system tumor was significantly increased. For persons with Klinefelter syndrome, the risk of solid tumors was decreased (SIR\u2009=\u20090.66), whereas the risk of hematological malignancy was increased (SIR\u2009=\u20092.72). Non\u2010Hodgkin lymphoma and leukemia showed an increased SIR of 3.02 and 3.62, respectively. Our study supported the hypothesis that X chromosome plays an important role in the etiology of solid tumors. The underlying mechanisms for the increased incidence of non\u2010Hodgkin lymphoma and leukemia in persons with Klinefelter syndrome need to be investigated further.<\/jats:p>","DOI":"10.1002\/ijc.30126","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T17:42:22Z","timestamp":1460310142000},"page":"754-758","source":"Crossref","is-referenced-by-count":108,"title":["Risk of solid tumors and hematological malignancy in persons with Turner and Klinefelter syndromes: A national cohort study"],"prefix":"10.1002","volume":"139","author":[{"given":"Jianguang","family":"Ji","sequence":"first","affiliation":[{"name":"Center for Primary Health Care Research, Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Z\u00f6ller","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Lund University Lund Sweden"},{"name":"Stanford Prevention Research Center, Stanford University School of Medicine Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Lund University Lund Sweden"},{"name":"Stanford Prevention Research Center, Stanford University School of Medicine Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cxom.2014.05.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70153-0"},{"key":"e_1_2_6_4_1","volume-title":"Blueprints pediatrics","author":"Marino BS.","year":"2013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16678-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2012.00268"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2394"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2815"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201100047"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.11.012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.11.015"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1383725"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15541-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21696"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1423.010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.12.014"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.07.100"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1182\/blood.V72.1.15.15","article-title":"Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome","volume":"72","author":"Hayashi Y","year":"1988","journal-title":"Blood"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05201-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2091"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02917"},{"key":"e_1_2_6_22_1","first-page":"2686","article-title":"[Klinefelter syndrome affects mostly boys. 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