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It is unknown if this is due to a higher prevalence of human herpesvirus 8 (HHV\u20108), the underlying cause of KS, in men compared to women. We did a systematic review and meta\u2010analysis to examine the association between HHV\u20108 seropositivity and gender in the general population. Studies in selected populations like for example, blood donors, hospital patients and men who have sex with men were excluded. We searched Medline and Embase from January 1994 to February 2015. We included observational studies that recruited participants from the general population and reported HHV\u20108 seroprevalence for men and women or boys and girls. We used random\u2010effects meta\u2010analysis to pool odds ratios (OR) of the association between HHV\u20108 and gender. We used meta\u2010regression to identify effect modifiers, including age, geographical region and type of HHV\u20108 antibody test. We included 22 studies, with 36,175 participants. Men from sub\u2010Saharan Africa (SSA) [OR 1.21, 95% confidence interval (CI) 1.09\u20131.34], but not men from elsewhere (OR 0.94, 95% CI 0.83\u20131.06), were more likely to be HHV\u20108 seropositive than women (<jats:italic>p<\/jats:italic> value for interaction\u2009=\u20090.010). There was no difference in HHV\u20108 seroprevalence between boys and girls from SSA (OR 0.90, 95% CI 0.72\u20131.13). The type of HHV\u20108 assay did not affect the overall results. A higher HHV\u20108 seroprevalence in men than women in SSA may partially explain why men have a higher KS risk in this region.<\/jats:p>","DOI":"10.1002\/ijc.30129","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T17:42:19Z","timestamp":1460310139000},"page":"776-783","source":"Crossref","is-referenced-by-count":36,"title":["Is human herpesvirus 8 infection more common in men than in women? 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