{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:52:29Z","timestamp":1771037549938,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T00:00:00Z","timestamp":1463184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>In our previous study of the etiologic role of oncogenic human papillomavirus (HPV) types other than HPV16 and 18, we observed a significantly higher risk of cervical intraepithelial neoplasia Grades 2\u20133 (CIN2\/3) associated with certain lineages of HPV types 31\/33\/45\/56\/58 [called high\u2010risk (HR) variants] compared with non\u2010HR variants. This study was to examine whether these intra\u2010type variants differ in persistence of the infection and persistence\u2010associated risk of CIN2\/3. Study subjects were women who had any of HPV types 31\/33\/45\/56\/58 newly detected during a 2\u2010year follow\u2010up with 6\u2010month intervals. For each type, the first positive sample was used for variant characterization. The association of reverting\u2010to\u2010negativity with group of the variants and CIN2\/3 with length of positivity was assessed using discrete Cox regression and logistic regression, respectively. Of the 598 newly detected, type\u2010specific HPV infections, 312 became undetectable during follow\u2010up. Infections with HR, compared with non\u2010HR, variants were marginally more likely to become negative [adjusted hazard ratio\u2009=\u20091.3; 95% confidence interval (CI), 0.9\u20131.8]. The adjusted odds ratio associating with the development of CIN2\/3 was 3.0 (95% CI, 1.2\u20137.4) for persistent infections with HR variants for 6 months and 10.0 (95% CI, 3.8\u201338.0) for persistent infections with HR variants for 12\u201318 months as compared with the first positive detection of HR variants. Among women with non\u2010HR variants, there were no appreciable differences in risk of CIN2\/3 by length of positivity. Findings suggest that the lineage\u2010associated risk of CIN2\/3 was not mediated through a prolonged persistent infection, but oncogenic heterogeneity of the variants.<\/jats:p>","DOI":"10.1002\/ijc.30164","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T09:34:47Z","timestamp":1461836087000},"page":"1098-1105","source":"Crossref","is-referenced-by-count":20,"title":["Variant\u2010specific persistence of infections with human papillomavirus Types 31, 33, 45, 56 and 58 and risk of cervical intraepithelial neoplasia"],"prefix":"10.1002","volume":"139","author":[{"given":"Long Fu","family":"Xi","sequence":"first","affiliation":[{"name":"Department of Pathology School of Medicine, University of Washington Seattle WA"},{"name":"Department of Epidemiology School of Public Health and Community Medicine, University of Washington Seattle 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