{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:00:32Z","timestamp":1762210832223,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T00:00:00Z","timestamp":1464825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Centre for Clinical Research"},{"DOI":"10.13039\/501100009612","name":"V\u00e4stmanland County Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009612","id-type":"DOI","asserted-by":"crossref"}]},{"name":"InfCare HIV National Quality Assurance Registry"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>Little is known about the incidence and risk of cervical intraepithelial neoplasia (CIN) grade 3, adenocarcinoma in situ and invasive cervical cancer (CIN3+) among migrants living with HIV in a European setting. We assessed the cumulative incidence (CuI) and hazard ratio (HR) of CIN2+ and CIN3+ in a cohort of women living with HIV (WLWH) (<jats:italic>n<\/jats:italic>\u2009=\u2009893) identified from the Swedish national HIV register and HIV\u2010negative women (<jats:italic>n<\/jats:italic>\u2009=\u2009205,842) identified from the Swedish Population Register, matched on region of birth and age. Data was collected between 1993 and 2011 by linking our cohort with the Swedish National Cervical Screening Registry, collecting all cytological and histological results since 1993. The CuI of CIN3+ was 13.1% [95% confidence interval (CI) 8.9\u201317.2] for WLWH and 2.1% (95% CI 2.0\u20132.2) for HIV\u2010negative after 18 years of follow\u2010up. WLWH had more than eight times higher, age and region of birth matched, risk of CIN3+ than HIV\u2010negative (HR 8.8: 95% CI 6.9\u201311.3). WLWH born in the East region, dominated by Thai women, had a two times higher risk of CIN3+ compared with WLWH born in Sweden (HR 2.47: 95% CI 1.2\u20135.0), which remained after adjusting for immunosuppression. Our results showed a substantially increased risk of CIN3+ among WLWH, which differed depending on birth region. Early HIV diagnosis and attendance to cervical cancer screening, with focus on migrants, is of crucial importance to minimize the incidence of cervical intraepithelial neoplasia.<\/jats:p>","DOI":"10.1002\/ijc.30188","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T16:14:35Z","timestamp":1463156075000},"page":"1471-1479","source":"Crossref","is-referenced-by-count":13,"title":["Impact of immunosuppression and region of birth on risk of cervical intraepithelial neoplasia among migrants living with HIV in Sweden"],"prefix":"10.1002","volume":"139","author":[{"given":"Christina","family":"Carlander","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases and Dermatology Department of Medicine Huddinge Karolinska Institutet Stockholm Sweden"},{"name":"Centre for Clinical Research County Hospital V\u00e4ster\u00e5s V\u00e4ster\u00e5s Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Wagner","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research County Hospital V\u00e4ster\u00e5s V\u00e4ster\u00e5s Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Svedhem","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases and Dermatology Department of Medicine Huddinge Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Elfgren","sequence":"additional","affiliation":[{"name":"CLINTEC Department of Obstetrics and Gynaecology Karolinska University Hospital Huddinge Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Westling","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases and Dermatology Department of Medicine Huddinge Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"S\u00f6nnerborg","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases and Dermatology Department of Medicine Huddinge Karolinska Institutet Stockholm Sweden"},{"name":"Division of Clinical Microbiology Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4r","family":"Spar\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.16.1.18023"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000455"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp205"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.12.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70282-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9475-z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29913"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/650467"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.15.2.17382"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2012.012040"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4344-8"},{"key":"e_1_2_6_13_1","unstructured":"Fact sheets by population.International Agency for Research on Cancer (IARC).http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_population.aspx. 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