{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:24:52Z","timestamp":1791602692037,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T00:00:00Z","timestamp":1466121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 81172"],"award-info":[{"award-number":["MOP 81172"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 111207"],"award-info":[{"award-number":["MOP 111207"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>\n                    Some studies suggest that periodontal diseases increase the risk of oral cancer, but contradictory results also exist. Inadequate control of confounders, including life course exposures, may have influenced prior findings. We estimate the extent to which high levels of periodontal diseases, measured by gingival inflammation and recession, are associated with oral cancer risk using a comprehensive subset of potential confounders and applying a stringent adjustment approach. In a hospital\u2010based case\u2010control study, incident oral cancer cases (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009350) were recruited from two major referral hospitals in Kerala, South India, from 2008 to 2012. Controls (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009371), frequency\u2010matched by age and sex, were recruited from clinics at the same hospitals. Structured interviews collected information on several domains of exposure via a detailed life course questionnaire. Periodontal diseases, as measured by gingival inflammation and gingival recession, were evaluated visually by qualified dentists following a detailed protocol. The relationship between periodontal diseases and oral cancer risk was assessed by unconditional logistic regression using a stringent empirical selection of potential confounders corresponding to a 1% change\u2010in\u2010estimates. Generalized gingival recession was significantly associated with oral cancer risk (Odds Ratio\u2009=\u20091.83, 95% Confidence Interval: 1.10\u20133.04). No significant association was observed between gingival inflammation and oral cancer. Our findings support the hypothesis that high levels of periodontal diseases increase the risk of oral cancer.\n                  <\/jats:p>","DOI":"10.1002\/ijc.30201","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T12:49:02Z","timestamp":1464094142000},"page":"1512-1519","source":"Crossref","is-referenced-by-count":123,"title":["Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study"],"prefix":"10.1002","volume":"139","author":[{"given":"Claudie","family":"Laprise","sequence":"first","affiliation":[{"name":"Department of Oncology Division of Cancer Epidemiology McGill University Montreal QC Canada"},{"name":"Division of Oral Health and Society Faculty of Dentistry McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hameed Puthiyannal","family":"Shahul","sequence":"additional","affiliation":[{"name":"Division of Oral Health and Society Faculty of Dentistry McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenath Arekunnath","family":"Madathil","sequence":"additional","affiliation":[{"name":"Division of Oral Health and Society Faculty of Dentistry McGill University Montreal QC Canada"},{"name":"Epidemiology and Biostatistics Unit INRS\u2010Institut Armand\u2010Frappier Laval QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil Soman","family":"Thekkepurakkal","sequence":"additional","affiliation":[{"name":"Division of Oral Health and Society Faculty of Dentistry McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Castonguay","sequence":"additional","affiliation":[{"name":"Division of Oral Health and Society Faculty of Dentistry McGill University Montreal QC 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