{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:08:26Z","timestamp":1781712506346,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Although mammography screening programs do not include ultrasound examinations, some diagnostic units do provide women with both mammography and ultrasonography. This article is concerned with estimating the risk of a breast cancer patient diagnosed in a hospital\u2010based mammography unit having a tumor that is visible on ultrasound but not on mammography. A total of 1,399 women with invasive breast cancer from a hospital\u2010based diagnostic mammography unit were included in this retrospective study. For inclusion, mammograms from the time of the primary diagnosis had to be available for computer\u2010assisted assessment of percentage mammographic density (PMD), as well as Breast Imaging Reporting and Data System (BIRADS) assessment of mammography. In addition, ultrasound findings were available for the complete cohort as part of routine diagnostic procedures, regardless of any patient or imaging characteristics. Logistic regression analyses were conducted to identify predictors of mammography failure, defined as BIRADS assessment 1 or 2. The probability that the visibility of a tumor might be masked at diagnosis was estimated using a regression model with the identified predictors. Tumors were only visible on ultrasound in 107 cases (7.6%). PMD was the strongest predictor for mammography failure, but age, body mass index and previous breast surgery also influenced the risk, independently of the PMD. Risk probabilities ranged from 1% for a defined low\u2010risk group up to 40% for a high\u2010risk group. These findings might help identify women who should be offered ultrasound examinations in addition to mammography.<\/jats:p>","DOI":"10.1002\/ijc.30261","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T09:48:10Z","timestamp":1467971290000},"page":"1967-1974","source":"Crossref","is-referenced-by-count":24,"title":["Mammographic density is the main correlate of tumors detected on ultrasound but not on mammography"],"prefix":"10.1002","volume":"139","author":[{"given":"Lothar","family":"H\u00e4berle","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics University Breast Center for Franconia, Erlangen University Hospital, Germany, Friedrich Alexander University of Erlangen\u2013Nuremberg, Comprehensive Cancer Center Erlangen\u2010EMN Erlangen Germany"},{"name":"Biostatistics Unit, Department of Gynecology and Obstetrics Erlangen University Hospital Erlangen 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Franconia, Erlangen University Hospital, Germany, Friedrich Alexander University of Erlangen\u2013Nuremberg, Comprehensive Cancer Center Erlangen\u2010EMN Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin C.","family":"Hack","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics University Breast Center for Franconia, Erlangen University Hospital, Germany, Friedrich Alexander University of Erlangen\u2013Nuremberg, Comprehensive Cancer Center Erlangen\u2010EMN Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Preuss","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics University Breast Center for Franconia, Erlangen University Hospital, Germany, Friedrich Alexander University of Erlangen\u2013Nuremberg, Comprehensive Cancer Center Erlangen\u2010EMN Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Lux","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics University Breast Center for Franconia, Erlangen University Hospital, Germany, Friedrich Alexander University of Erlangen\u2013Nuremberg, Comprehensive Cancer Center Erlangen\u2010EMN Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Erlangen University Hospital, Friedrich Alexander University of Erlangen\u2013Nuremberg, Comprehensive Cancer Center Erlangen\u2010EMN Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine M.","family":"Vachon","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Health Sciences Research Mayo Clinic Rochester 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Friedrich Alexander University of Erlangen\u2013Nuremberg, Comprehensive Cancer Center Erlangen\u2010EMN Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Schulz\u2010Wendtland","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Erlangen University Hospital, Friedrich Alexander University of Erlangen\u2013Nuremberg, University Breast Center for Franconia, Comprehensive Cancer Center Erlangen\u2010EMN Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1328075"},{"key":"e_1_2_7_3_1","first-page":"278","article-title":"Breast cancer diagnosed early and safe\u2014almost always cured?","volume":"72","author":"Katalinic A","year":"2012","journal-title":"Geburtsh 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