{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:46:09Z","timestamp":1787319969611,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["SB\/YS\/LS\u2010289\/2013"],"award-info":[{"award-number":["SB\/YS\/LS\u2010289\/2013"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>\n                    Mesenchymal stem cells (MSCs) represent an important cellular constituent of the tumor microenvironment, which along with tumor cells themselves, serve to regulate protective immune responses in support of progressive disease. We report that tumor MSCs prevent the ability of dendritic cells (DC) to promote na\u00efve CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell expansion, interferon gamma secretion and cytotoxicity against tumor cells, which are critical to immune\u2010mediated tumor eradication. Notably, tumor MSCs fail to prevent DC\u2010mediated early T cell activation events or the ability of responder T cells to produce IL\u20102. The immunoregulatory activity of tumor MSCs is IL\u201010\u2010 and STAT3\u2010dependent, with STAT3 repressing DC expression of cystathionase, a critical enzyme that converts methionine\u2010to\u2010cysteine. Under cysteine\u2010deficient priming conditions, na\u00efve T cells exhibit defective cellular metabolism and proliferation. Bioinformatics analyses as well as\n                    <jats:italic>in vitro<\/jats:italic>\n                    observations suggest that STAT3 may directly bind to a GAS\u2010like motif within the cystathionase promoter (\u2212269 to \u2212261) leading to IL\u201010\u2010STAT3 mediated repression of cystathionase gene transcription. Our collective results provide evidence for a novel mechanism of tumor MSC\u2010mediated T cell inhibition within tumor microenvironment.\n                  <\/jats:p>","DOI":"10.1002\/ijc.30265","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T22:26:45Z","timestamp":1468362405000},"page":"2068-2081","source":"Crossref","is-referenced-by-count":39,"title":["Tumor\u2010associated mesenchymal stem cells inhibit na\u00efve T cell expansion by blocking cysteine export from dendritic cells"],"prefix":"10.1002","volume":"139","author":[{"given":"Tithi","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Immunoregulation and Immunodiagnostics Chittaranjan National Cancer Institute (CNCI) Kolkata West Bengal 700026 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasis","family":"Barik","sequence":"additional","affiliation":[{"name":"Department of Immunoregulation and Immunodiagnostics Chittaranjan National 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