{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:15:17Z","timestamp":1788322517866,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:00:00Z","timestamp":1469577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000032","name":"Institute of Infection and Immunity","doi-asserted-by":"publisher","award":["R\u00edo Hortega CM13\/00232"],"award-info":[{"award-number":["R\u00edo Hortega CM13\/00232"]}],"id":[{"id":"10.13039\/501100000032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000032","name":"Institute of Infection and Immunity","doi-asserted-by":"publisher","award":["M\u2010AES MV15\/00025, PI11\/01810, PI11\/01889, PI14\/01219"],"award-info":[{"award-number":["M\u2010AES MV15\/00025, PI11\/01810, PI11\/01889, PI14\/01219"]}],"id":[{"id":"10.13039\/501100000032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Chronic lymphocytic leukemia (CLL) has few known modifiable risk factors. Recently, circadian disruption has been proposed as a potential contributor to lymphoid neoplasms' etiology. Serum melatonin levels have been found to be significantly lower in CLL subjects compared with healthy controls, and also, CLL prognosis has been related to alterations in the circadian molecular signaling. We performed the first investigation of an association between night shift work and CLL in 321 incident CLL cases and 1728 population\u2010based controls in five areas of Spain. Participants were interviewed face\u2010to\u2010face by trained interviewers to collect information on sociodemographic factors, familial, medical and occupational history, including work shifts and other lifestyle factors. We used logistic regression models adjusted for potential confounders to estimate odds ratios (OR) and 95% confidence intervals (CI). Seventy\u2010nine cases (25%) and 339 controls (20%) had performed night work. Overall, working in night shifts was not associated with CLL (OR\u2009=\u20091.06; 95% CI\u2009=\u20090.78\u20131.45, compared with day work). However, long\u2010term night shift (&gt;20 years) was positively associated with CLL (OR<jats:sub>(tertile 3<\/jats:sub> <jats:sub><jats:italic>vs<\/jats:italic><\/jats:sub><jats:sub>. day\u2010work)<\/jats:sub>\u2009=\u20091.77; 95%\u2009=\u20091.14\u20132.74), although no linear trend was observed (<jats:italic>P<\/jats:italic> trend\u2009=\u20090.18). This association was observed among those with rotating (OR<jats:sub>(tertile 3<\/jats:sub> <jats:sub><jats:italic>vs<\/jats:italic><\/jats:sub><jats:sub>. day\u2010work)<\/jats:sub>\u2009=\u20092.29; 95% CI\u2009=\u20091.33\u20133.92; <jats:italic>P t<\/jats:italic>rend\u2009=\u20090.07), but not permanent night shifts (OR<jats:sub>(tertile 3<\/jats:sub> <jats:sub><jats:italic>vs<\/jats:italic><\/jats:sub><jats:sub>. day\u2010work)<\/jats:sub> = 1.16; 95% CI\u2009=\u20090.60\u20132.25; <jats:italic>P<\/jats:italic> trend\u2009=\u20090.86). The association between CLL and long\u2010term rotating night shift warrants further investigation.<\/jats:p>","DOI":"10.1002\/ijc.30272","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T23:27:58Z","timestamp":1468538878000},"page":"1994-2000","source":"Crossref","is-referenced-by-count":20,"title":["Night shift work and chronic lymphocytic leukemia in the MCC\u2010Spain case\u2013control study"],"prefix":"10.1002","volume":"139","author":[{"given":"Laura","family":"Costas","sequence":"first","affiliation":[{"name":"Unit of Infections and Cancer, Cancer Epidemiology Research Programme IDIBELL, Catalan Institute of Oncology Barcelona Spain"},{"name":"Department of Medicine University of Barcelona Barcelona Spain"},{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Benavente","sequence":"additional","affiliation":[{"name":"Unit of Infections and Cancer, Cancer Epidemiology Research Programme IDIBELL, Catalan Institute of Oncology Barcelona Spain"},{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Olmedo\u2010Requena","sequence":"additional","affiliation":[{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP)  Spain"},{"name":"Department of Preventive Medicine and Public Health University of Granada Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs, Granada, Complejo Hospitales Universitarios de Granada, Universidad de Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Casabonne","sequence":"additional","affiliation":[{"name":"Unit of Infections and Cancer, Cancer Epidemiology Research Programme IDIBELL, Catalan Institute of Oncology Barcelona Spain"},{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Robles","sequence":"additional","affiliation":[{"name":"Unit of Infections and Cancer, Cancer Epidemiology Research Programme IDIBELL, Catalan Institute of Oncology Barcelona Spain"},{"name":"Prevention and Implementation Group International Agency for Research on Cancer Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva\u2010Maria","family":"Gonzalez\u2010Barca","sequence":"additional","affiliation":[{"name":"Hematology, IDIBELL, Institut Catal\u00e0 d' Oncologia 08908, L' Hospitalet De Llobregat Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmeralda","family":"de la Banda","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari de Bellvitge 08908, L'Hospitalet De Llobregat Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari de Bellvitge 08908, L'Hospitalet De Llobregat Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Aymerich","sequence":"additional","affiliation":[{"name":"Hematopathology Unit, Pathology Department Hospital Cl\u00ednic, University of Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS) Barcelona 08036 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adonina","family":"Tard\u00f3n","sequence":"additional","affiliation":[{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP)  Spain"},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), University of Oviedo  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Marcos\u2010Gragera","sequence":"additional","affiliation":[{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP)  Spain"},{"name":"Unitat d'Epidemiologia i Registre de C\u00e0ncer de Girona (UERCG), Pla Director d'Oncologia Institut Catal\u00e0 d'Oncologia, Institut d'Investigaci\u00f3 Biom\u00e8dica de Girona (IdIBGi), Universitat de Girona Girona 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Epidemiology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Casta\u00f1o\u2010Vinyals","sequence":"additional","affiliation":[{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP)  Spain"},{"name":"ISGlobal, Centre for Research in Environmental Epidemiology (CREAL) Barcelona Spain"},{"name":"Hospital del Mar Medical Research Institute (IMIM) Barcelona Spain"},{"name":"Universitat Pompeu Fabra (UPF) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Aragon\u00e9s","sequence":"additional","affiliation":[{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP)  Spain"},{"name":"Cancer and Environmental Epidemiology Unit National Center for Epidemiology, Carlos III Institute of Health Madrid 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