{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:39:59Z","timestamp":1787168399344,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the German Research Council","award":["BR 1704\/6-1"],"award-info":[{"award-number":["BR 1704\/6-1"]}]},{"name":"the German Research Council","award":["BR 1704\/6-3"],"award-info":[{"award-number":["BR 1704\/6-3"]}]},{"name":"the German Research Council","award":["BR 1704\/6-4"],"award-info":[{"award-number":["BR 1704\/6-4"]}]},{"name":"the German Research Council","award":["CH 117\/1-1"],"award-info":[{"award-number":["CH 117\/1-1"]}]},{"name":"the German Federal Ministry of Education and Research","award":["01KH0404"],"award-info":[{"award-number":["01KH0404"]}]},{"name":"the German Federal Ministry of Education and Research","award":["01ER0814"],"award-info":[{"award-number":["01ER0814"]}]},{"name":"the Interdisciplinary Research Program of the National Center for Tumor Diseases (NCT)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,11,15]]},"abstract":"<jats:p>Registry\u2010based studies on the risk of colorectal cancer (CRC) for persons with a family history (FH) typically did not control for important covariates, such as history of colonoscopy. We aimed to quantify the association between FH and CRC risk, carefully accounting for potential confounders. We conducted a population\u2010based case\u2013control study in Germany. A total of 4,313 patients with a first diagnosis of CRC (cases) and 3,153 controls recruited from 2003 to 2014 were included. We used multiple logistic regression analyses to assess the association between FH and risk of CRC with odds ratios (OR) and the resulting 95% confidence intervals (95% CI). A total of 582 cases (13.5%) and 321 (10.2%) controls reported a history of CRC in a first\u2010degree relative, which was associated with a 41% increase in risk of CRC (OR: 1.41, 95% CI 1.22\u20131.63) after adjustment for sex and age. The OR substantially increased to 1.73 (95% CI, 1.48\u20132.03) after comprehensive adjustment including previous colonoscopies. Irrespective of their FH status, persons with history of colonoscopies had a lower CRC risk compared with persons without previous colonoscopies and without family history (OR: 0.25, 95% CI, 0.22\u20130.28 for persons without FH and OR 0.45, 95% CI, 0.36\u20130.56 for persons with FH). In an era of widespread use of colonoscopy, adjusting for previous colonoscopy is therefore crucial for deriving valid estimates of FH\u2010related CRC risk. Colonoscopy reduces the risk of CRC among those with FH far below levels of people with no FH and no colonoscopy.<\/jats:p>","DOI":"10.1002\/ijc.30284","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T19:26:41Z","timestamp":1469561201000},"page":"2213-2220","source":"Crossref","is-referenced-by-count":14,"title":["Family history and the risk of colorectal cancer: The importance of patients' history of colonoscopy"],"prefix":"10.1002","volume":"139","author":[{"given":"Korbinian","family":"Weigl","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Jansen","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Chang\u2010Claude","sequence":"additional","affiliation":[{"name":"Unit of Genetic Epidemiology German Cancer Research Center (DKFZ) Heidelberg Germany"},{"name":"University Cancer Center Hamburg (UCCH) University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Knebel","sequence":"additional","affiliation":[{"name":"Department for General Visceral and Transplantation Surgery, University Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hoffmeister","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Brenner","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ) Heidelberg Germany"},{"name":"Division of Preventive Oncology German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg Germany"},{"name":"German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]","author":"Ferlay J","year":"2013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-0876-y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3467-x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.07.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.09.023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.11.044"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.06.040"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g2467"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.002"},{"key":"e_1_2_8_11_1","volume-title":"American Cancer Society recommendations for colorectal cancer early detection","author":"American Cancer Society","year":"2014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200607000-00006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2007.00834.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2006.12.016"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-1-201101040-00004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.09.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114174"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a121617"},{"key":"e_1_2_8_19_1","volume-title":"Proceedings of the 29th annual SAS users group international conference. 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