{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:51:29Z","timestamp":1789386689944,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T00:00:00Z","timestamp":1470787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["91033718830"],"award-info":[{"award-number":["91033718830"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,11,15]]},"abstract":"<jats:p>We aimed to determine the risk of advanced neoplasms among a cohort of asymptomatic first degree relatives (FDRs) of patients with sporadic colorectal cancer (CRC) compared with matched controls. Data for patients with a diagnosis of CRC made between September 2013 and August 2014 were obtained from a population\u2010based cancer registry system in Tehran. Screening colonoscopies were done for 342 FDRs and the findings were compared to those from 342 age\u2010 and gender\u2010matched healthy controls without a family history of CRC. We reported the association as conditional Odds Ratio (OR) using Mantel Hazel and Logistic regression. The prevalence of advanced neoplasia was 13.2% among FDRs and 3.8% in controls (matched OR [mOR], 4.0, 95% confidence interval [CI], 2.1 \u2013 7.6;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In FDRs aged 40\u201349 years, the prevalence of advanced neoplasia was significantly higher than in their matched controls (mOR, 6.8, 95% CI, 1.5\u201331.4;<jats:italic>p<\/jats:italic>\u2009=\u20090.01). Family history of CRC in at least one FDR was the strongest predictor of advanced neoplasia (adjusted OR, 4.0, 95% CI: 2.1\u20137.6;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The age of the index case at diagnosis did not predict the presence of advanced colonic neoplasms in their FDRs. Our study indicates a high risk of advanced neoplasia in FDRs of CRC cases, where only eight colonoscopies are needed to detect one advanced neoplasia. Our data suggest that all FDRs, regardless of the age of CRC diagnosis in their index case, should be considered for a targeted early screening.<\/jats:p>","DOI":"10.1002\/ijc.30366","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T06:27:01Z","timestamp":1470810421000},"page":"2243-2251","source":"Crossref","is-referenced-by-count":7,"title":["Advanced colonic neoplasia in the first degree relatives of colon cancer patients: A colonoscopy\u2010based study"],"prefix":"10.1002","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6471-0069","authenticated-orcid":false,"given":"Hamideh","family":"Salimzadeh","sequence":"first","affiliation":[{"name":"Digestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faraz","family":"Bishehsari","sequence":"additional","affiliation":[{"name":"Masoud 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