{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:59:34Z","timestamp":1790002774251,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"NIH\/NCI","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:p>\n                    Chronic Hepatitis C virus (HCV) infection is associated with increased incidence of non\u2010Hodgkin lymphoma. Several studies have demonstrated regression of indolent lymphoma with antiviral therapy (AVT) alone. However, the role of AVT in HCV\u2010infected patients with diffuse large B\u2010cell lymphoma (DLBCL) is unclear. We therefore analyzed AVT's impact on oncologic outcomes of HCV\u2010infected patients (cases) who developed DLBCL. Cases seen at our institution (June 2004\u2013May 2014) were matched with uninfected counterparts (controls) and then divided according to prior AVT consisting of interferon\u2010based regimens. We studied 304 patients (76 cases and 228 controls). More cases than controls had extranodal (79%\n                    <jats:italic>vs<\/jats:italic>\n                    . 72%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.07) and upper gastrointestinal (GI; 42%\n                    <jats:italic>vs<\/jats:italic>\n                    . 24%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004) involvement. Cases never given AVT had DLBCL more refractory to first\u2010line chemotherapy than that in the controls (33%\n                    <jats:italic>vs<\/jats:italic>\n                    . 17%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.05) and exhibited a trend toward more progressive lymphoma at last examination compared to controls (50%\n                    <jats:italic>vs<\/jats:italic>\n                    . 32%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.09) or cases given AVT (50%\n                    <jats:italic>vs<\/jats:italic>\n                    . 27%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.06). Cases never given AVT had worse 5\u2010year overall survival (OS) rates than did the controls (HR, 2.3 [95% CI, 1.01\u20135.3];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). Furthermore, AVT improved 5\u2010year OS rates among cases in both univariate (median [Interquartile range]: 39 [26\u201356]\n                    <jats:italic>vs.<\/jats:italic>\n                    16 [6\u201341] months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02) and multivariate analyses (HR\u2009=\u20090.21 [95% CI, 0.06\u20130.69];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). This study highlights the negative impact of chronic HCV on survival of DLBCL patients and shows that treatment of HCV infection is associated with a better cancer response to chemotherapy and improves 5\u2010year OS.\n                  <\/jats:p>","DOI":"10.1002\/ijc.30372","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T15:27:14Z","timestamp":1470670034000},"page":"2519-2528","source":"Crossref","is-referenced-by-count":31,"title":["Antiviral therapy improves overall survival in hepatitis C virus\u2010infected patients who develop diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"139","author":[{"given":"Jeff","family":"Hosry","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag","family":"Mahale","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Turturro","sequence":"additional","affiliation":[{"name":"Department of Lymphoma &amp; Myeloma The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto N.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minas P.","family":"Economides","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno P.","family":"Granwehr","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrys A.","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston 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