{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:01:09Z","timestamp":1791594069875,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:p>\n                    HPV testing is more sensitive than cytology for cervical screening. However, to incorporate HPV tests into screening, risk\u2010stratification (\u201ctriage\u201d) of HPV\u2010positive women is needed to avoid excessive colposcopy and overtreatment. We prospectively evaluated combinations of partial HPV typing (Onclarity, BD) and cytology triage, and explored whether management could be simplified, based on grouping combinations yielding similar 3\u2010year or 18\u2010month CIN3+ risks. We typed \u223c9,000 archived specimens, taken at enrollment (2007\u20132011) into the NCI\u2010Kaiser Permanente Northern California (KPNC) HPV Persistence and Progression (PaP) cohort. Stratified sampling, with reweighting in the statistical analysis, permitted risk estimation of HPV\/cytology combinations for the 700,000+\u2010woman KPNC screening population. Based on 3\u2010year CIN3+ risks, Onclarity results could be combined into five groups (HPV16, else HPV18\/45, else HPV31\/33\/58\/52, else HPV51\/35\/39\/68\/56\/66\/68, else HPV negative); cytology results fell into three risk groups (\u201chigh\u2010grade,\u201d ASC\u2010US\/LSIL, NILM). For the resultant 15 HPV group\u2010cytology combinations, 3\u2010year CIN3+ risks ranged 1,000\u2010fold from 60.6% to 0.06%. To guide management, we compared the risks to established \u201cbenchmark\u201d risk\/management thresholds in this same population (\n                    <jats:italic>e.g<\/jats:italic>\n                    ., LSIL predicted 3\u2010year CIN3+ risk of 5.8% in the screening population, providing the benchmark for colposcopic referral). By benchmarking to 3\u2010year risk thresholds (supplemented by 18\u2010month estimates), the widely varying risk strata could be condensed into four action bands (very high risk of CIN3+ mandating consideration of cone biopsy if colposcopy did not find precancer; moderate risk justifying colposcopy; low risk managed by intensified follow\u2010up to permit HPV \u201cclearance\u201d; and very low risk permitting routine screening.) Overall, the results support primary HPV testing, with management of HPV\u2010positive women using partial HPV typing and cytology.\n                  <\/jats:p>","DOI":"10.1002\/ijc.30375","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T19:12:46Z","timestamp":1470856366000},"page":"2606-2615","source":"Crossref","is-referenced-by-count":79,"title":["A cohort study of cervical screening using partial HPV typing and cytology triage"],"prefix":"10.1002","volume":"139","author":[{"given":"Mark","family":"Schiffman","sequence":"first","affiliation":[{"name":"National Cancer Institute Division of Cancer Epidemiology and Genetics Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noorie","family":"Hyun","sequence":"additional","affiliation":[{"name":"National Cancer Institute Division of Cancer Epidemiology and Genetics Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina R.","family":"Raine\u2010Bennett","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research Oakland CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hormuzd","family":"Katki","sequence":"additional","affiliation":[{"name":"National Cancer Institute Division of Cancer Epidemiology and Genetics Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Fetterman","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Regional Laboratory Berkeley CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C.","family":"Gage","sequence":"additional","affiliation":[{"name":"National Cancer Institute Division of Cancer Epidemiology and Genetics Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li C.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Information Management Services Calverton MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Befano","sequence":"additional","affiliation":[{"name":"Information Management Services Calverton MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Poitras","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Regional Laboratory Berkeley CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lorey","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Regional Laboratory Berkeley CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip E.","family":"Castle","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Wentzensen","sequence":"additional","affiliation":[{"name":"National Cancer Institute Division of Cancer Epidemiology and Genetics Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61416-0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21139"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju153"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.11.015"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000632"},{"key":"e_1_2_5_8_1","article-title":"Primary HPV testing: a proposal for co\u2010testing in initial rounds of screening to optimise sensitivity of cervical cancer screening","author":"Herbert A.","journal-title":"Cytopathology"},{"key":"e_1_2_5_9_1","first-page":"178","article-title":"Use of primary high\u2010risk human papillomavirus testing for cervical cancer screening: interim Clinical Guidance","volume":"136","author":"Huh WK","year":"2015","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02116-14"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.06.040"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.088"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00422-11"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP53KMHNRDICBL"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000170"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-1267"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181996ffa"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2008.05.017"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2007.06.001"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.04.015"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780071106"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532360"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780121706"},{"key":"e_1_2_5_24_1","volume-title":"Order restricted inference","author":"Robertson T","year":"1988"},{"key":"e_1_2_5_25_1","volume-title":"Practical methods of optimization","author":"Fletcher R.","year":"1987"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e318285423c"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70145-0"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0b013e31805152ab"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02068-08"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27485"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj067"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3182854282"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182883a34"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29143"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.9948"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e318285437b"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405044"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.13503"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70188-7"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.02.002"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1812"},{"key":"e_1_2_5_42_1","first-page":"108","article-title":"HPV16 sublineage associations with histology\u2010specific cancer risk using HPV whole\u2010genome sequences in 3200 women","volume":"9","author":"Mirabello L","year":"2016","journal-title":"J Natl Cancer Inst"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.30375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.30375","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.30375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.30375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.30375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:59:30Z","timestamp":1789999170000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.30375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,26]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,12,1]]}},"alternative-id":["10.1002\/ijc.30375"],"URL":"https:\/\/doi.org\/10.1002\/ijc.30375","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,26]]}}}