{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:48:45Z","timestamp":1789609725774,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"GlaxoSmithKline Biologicals SA (GSK)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,12,15]]},"abstract":"<jats:p>\n                    We evaluated the efficacy of the human papillomavirus (HPV)\u221216\/18 AS04\u2010adjuvanted vaccine in preventing HPV\u2010related disease after surgery for cervical lesions in a\n                    <jats:italic>post\u2010hoc<\/jats:italic>\n                    analysis of the PApilloma TRIal against Cancer In young Adults (PATRICIA; NCT00122681). Healthy women aged 15\u201325 years were randomized (1:1) to receive vaccine or control at months 0, 1 and 6 and followed for 4 years. Women were enrolled regardless of their baseline HPV DNA status, HPV\u201016\/18 serostatus, or cytology, but excluded if they had previous or planned colposcopy. The primary and secondary endpoints of PATRICIA have been reported previously; the present\n                    <jats:italic>post\u2010hoc<\/jats:italic>\n                    analysis evaluated efficacy in a subset of women who underwent an excisional procedure for cervical lesions after vaccination. The main outcome was the incidence of subsequent HPV\u2010related cervical intraepithelial neoplasia grade 2 or greater (CIN2+) 60 days or more post\u2010surgery. Other outcomes included the incidence of HPV\u2010related CIN1+, and vulvar or vaginal intraepithelial neoplasia (VIN\/VaIN) 60 days or more post\u2010surgery. Of the total vaccinated cohort of 18,644 women (vaccine\u2009=\u20099,319; control\u2009=\u20099,325), 454 (vaccine\u2009=\u2009190, control\u2009=\u2009264) underwent an excisional procedure during the trial. Efficacy 60 days or more post\u2010surgery for a first lesion, irrespective of HPV DNA results, was 88.2% (95% CI: 14.8, 99.7) against CIN2+ and 42.6% (\u221221.1, 74.1) against CIN1+. No VIN was reported and one woman in each group had VaIN2+ 60 days or more post\u2010surgery. Women who undergo surgical therapy for cervical lesions after vaccination with the HPV\u201016\/18 vaccine may continue to benefit from vaccination, with a reduced risk of developing subsequent CIN2+.\n                  <\/jats:p>","DOI":"10.1002\/ijc.30391","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T13:52:42Z","timestamp":1471614762000},"page":"2812-2826","source":"Crossref","is-referenced-by-count":103,"title":["Prior human papillomavirus\u201016\/18 AS04\u2010adjuvanted vaccination prevents recurrent high grade cervical intraepithelial neoplasia after definitive surgical therapy:\n                    <i>Post\u2010hoc<\/i>\n                    analysis from a randomized controlled trial"],"prefix":"10.1002","volume":"139","author":[{"given":"Suzanne M.","family":"Garland","sequence":"first","affiliation":[{"name":"Microbiology and Infectious Diseases Department Royal Women's Hospital and Department of Obstetrics and Gynaecology, University of Melbourne  VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma","family":"Paavonen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Helsinki  Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unnop","family":"Jaisamrarn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Naud","sequence":"additional","affiliation":[{"name":"University Federal of Rio Grande do Sul, Hospital de Cl\u00ednica de Porto Alegre  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Salmer\u00f3n","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Epidemiol\u00f3gica y en Servicios de Salud, Instituto Mexicano del Seguro Social  Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song\u2010Nan","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine and the Hospital, National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Apter","sequence":"additional","affiliation":[{"name":"Family Federation of Finland, Sexual Health Clinic, Helsinki, Finland to VL\u2010Medi Research Center Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Castellsagu\u00e9","sequence":"additional","affiliation":[{"name":"Institut Catal\u00e0 d'Oncologia, L'Hospitalet de Llobregat, IDIBELL, CIBER\u2010ESP  Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falio C.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Gynecology Oncology Division\u2014CAISM, State University of Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Rachel","family":"Skinner","sequence":"additional","affiliation":[{"name":"Vaccine Trials Group Telethon Institute for Child Health Research Sydney NSW Australia"},{"name":"Sydney University Discipline of Paediatrics and Child Health, Children's Hospital at Westmead Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Hedrick","sequence":"additional","affiliation":[{"name":"Kentucky Pediatric and Adult Research Bardstown KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genara","family":"Limson","sequence":"additional","affiliation":[{"name":"Makati Medical Centre University of the Philippines, College of Medicine, Philippine General Hospital Makati City Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tino F.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Central Laboratory and Vaccination Centre Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willy A.J.","family":"Poppe","sequence":"additional","affiliation":[{"name":"Department of Gynaecology University Hospital KU Leuven Gasthuisberg Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Xavier","family":"Bosch","sequence":"additional","affiliation":[{"name":"Institut Catal\u00e0 d'Oncologia, L'Hospitalet de Llobregat, IDIBELL, CIBER\u2010ESP  Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Newton S.","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Federal University of Paran\u00e1, Infectious Diseases in Gynecology and Obstetrics Sector Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Julieta V.","family":"Germar","sequence":"additional","affiliation":[{"name":"University of the Philippines College of Medicine, Philippine General Hospital Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Peters","sequence":"additional","affiliation":[{"name":"Facharzt f\u00fcr Frauenheilkunde und Geburtshilfe Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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