{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:31:03Z","timestamp":1787740263498,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Richard B. Salomon Faculty Research Award of Brown University, Research Career Development Award of Dermatology Foundation"},{"name":"National Institutes of Health grant for Health Professionals Follow-up Study","award":["UM1 CA167552"],"award-info":[{"award-number":["UM1 CA167552"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,12,15]]},"abstract":"<jats:p><jats:bold>We examined the association between male\u2010pattern baldness and risk of incident skin cancer, including invasive melanoma, invasive squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) in a prospective analysis, based on 36,032 participants from the Health Professionals' Follow\u2010up Study. In 1992, participants reported their status of male\u2010pattern baldness at age 45 years by choosing from five crown\u2010view pictograms based on Norwood's classification. Diagnosis of skin cancers was reported biennially and information on melanoma and SCC was pathologically confirmed. We identified 327 melanoma cases, 1324 SCC cases, and 8438 BCC cases during the follow\u2010up. Male\u2010pattern baldness was not significantly associated with risk of incident melanoma, but was significantly associated with increased risk of SCC and BCC. The multivariate\u2010adjusted hazard ratio (HR) (95% confidence interval, CI) for the highest category of baldness (frontal plus severe vertex baldness) was 1.33 (1.06\u20131.68) for SCC (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.001) and 1.23 (1.12\u20131.35) for BCC (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009&lt;\u20090.0001), compared with no baldness. Analyses by body sites found significant associations between frontal plus moderate to severe vertex baldness and risk of melanoma (HR\u2009=\u20091.83, 95% CI: 1.01\u20133.34) and SCC (HR\u2009=\u20091.30, 95% CI: 1.02\u20131.66) at head and neck. The associations were particularly stronger for scalp melanoma (HR\u2009=\u20097.15, 95% CI: 1.29\u201339.42) and scalp SCC (HR\u2009=\u20097.09, 95% CI: 3.84\u201313.08), but not for non\u2010scalp head and neck sites. Information on body sites was not available for BCC. In conclusion, male pattern baldness may be associated with increased risk of skin cancer, but the associations may only exist for those occurring at head and neck, particularly at scalp.<\/jats:bold><\/jats:p>","DOI":"10.1002\/ijc.30395","type":"journal-article","created":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T09:02:59Z","timestamp":1471683779000},"page":"2671-2678","source":"Crossref","is-referenced-by-count":31,"title":["Male pattern baldness and risk of incident skin cancer in a cohort of men"],"prefix":"10.1002","volume":"139","author":[{"given":"Wen\u2010Qing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology Brown University, Warren Alpert Medical School Providence RI"},{"name":"Department of Epidemiology, School of Public Health Brown University Providence RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunyoung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Dermatology Brown University, Warren Alpert Medical School Providence RI"},{"name":"Department of Epidemiology, School of Public Health Brown University Providence RI"},{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Han","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA"},{"name":"Department of Epidemiology, Richard M. Fairbanks School of Public Health Indiana University Indianapolis IN"},{"name":"Melvin and Bren Simon Cancer Center, Indiana University Indianapolis IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Weinstock","sequence":"additional","affiliation":[{"name":"Department of Dermatology Brown University, Warren Alpert Medical School Providence RI"},{"name":"Department of Epidemiology, School of Public Health Brown University Providence RI"},{"name":"Center for Dermatoepidemiology, VA Medical Center Providence RI"},{"name":"Department of Dermatology Rhode Island Hospital Providence RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrar A.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Brown University, Warren Alpert Medical School Providence RI"},{"name":"Department of Epidemiology, School of Public Health Brown University Providence RI"},{"name":"Channing Division of Network Medicine, 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