{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:06:11Z","timestamp":1781579171244,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T00:00:00Z","timestamp":1473811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2016,12,15]]},"abstract":"<jats:p>We investigated HPV in adenocarcinoma presenting and managed as cervical adenocarcinoma (CADC) at seven major representative regional cancer centres across China. From 1,051 CADC cases diagnosed locally in 2005\u20132010, 881 had available paraffin embedded tissue. Initial review excluded 154 cases as other diagnoses or inappropriate specimens. In 718 eligible cases consensus panel pathology diagnosis was made using an algorithm incorporating p16 and progesterone receptor immunohistochemistry (IHC). Classification of cervical adenocarcinoma categories was subject to substantial pathological disagreement. High\u2010risk human papillomaviruses (HR\u2010HPV) DNA was studied by the sensitive SPF10 PCR\u2010DEIA\u2010LiPA25 version 1 for L1 genes and type\u2010specific HR\u2010HPV E6\/7 gene PCR's. HR\u2010HPV prevalence in whole tissue samples in eligible tested CADC was 74.5%: 100.0% in neuro\u2010endocrine carcinoma (NEC), 82.2% in classical cervical adenocarcinoma (ADC\u2010CX), 40.0% in adenocarcinoma\u2010not otherwise specified (ADC\u2010NOS) and 33.3% in endometrioid adenocarcinoma (ADC\u2010ENDO). Higher mean age at diagnosis correlated with histological categories showing low HPV prevalence (Linear regression: <jats:italic>\u03b2<\/jats:italic>= \u221213.794, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). HPV\u201016 and 18 were associated with early development of CADC and a lower mean age correlated with carcinogenic risk of associated HPV (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.1829, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). HPV\u201016 or HPV\u201018 was found in 88.2% of all HPV positive cases including multiple\u2010infections. HPV\u201018 was the commonest HPV type in NEC (58.3%), ASC (40.2%) and ADC\u2010CX (40.9%). The proportion of HPV\u2010unrelated CADC and in different final histological categories varied geographically and by age. Although HPV negativity was predominantly associated with special categories of CADC, some HPV\u2010negative usual adenocarcinomas indistinguishable by adjudicated microscopic diagnosis from ADC\u2010CX were found and varied in frequency across China.<\/jats:p>","DOI":"10.1002\/ijc.30401","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T04:58:54Z","timestamp":1472014734000},"page":"2687-2697","source":"Crossref","is-referenced-by-count":33,"title":["The variable clinicopathological categories and role of human papillomavirus in cervical adenocarcinoma: A hospital based nation\u2010wide multi\u2010center retrospective study across China"],"prefix":"10.1002","volume":"139","author":[{"given":"Wen","family":"Chen","sequence":"first","affiliation":[{"name":"Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 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