{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:05:48Z","timestamp":1740103548092,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T00:00:00Z","timestamp":1474675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Interval breast cancer (IC) has a more aggressive phenotype and higher mortality than screen\u2010detected cancer (SDC). In this case\u2010case study, we investigated whether the size of longitudinal fluctuations in mammographic percent density (PD fluctuation) was associated with the ratio of IC <jats:italic>versus<\/jats:italic> SDC among screened women with breast cancer. The primary study population consisted of 1,414 postmenopausal breast cancer cases, and the validation population of 1,241 cases. We calculated PD fluctuation as the quadratic mean of deviations between actual PD and the long\u2010term trend estimated by a mixed effects model. In a logistic regression model we examined the association between PD fluctuation and IC <jats:italic>versus<\/jats:italic> SDC including adjustments for PD at last screening, age at diagnosis, BMI and hormone replacement therapy. All statistical tests were two\u2010sided. There were 385 IC and 1,029 SDC in the primary study population, with PD fluctuations of 0.44 and 0.41 respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.0309). After adjustments, PD fluctuation was associated with an increased ratio of IC <jats:italic>versus<\/jats:italic> SDC, with an estimated per\u2010standard deviation odds ratio of 1.17 (95% CI\u2009=\u20091.03\u20131.33), compared to 1.19 (95% CI\u2009=\u20091.04\u20131.38) in the validation population. In screened women with breast cancer, high fluctuation in mammographic percent density was associated with an increased ratio of IC <jats:italic>versus<\/jats:italic> SDC. Whether this is entirely related to a reduced mammographic detectability or to a biological phenotype promoting faster tumor growth remains to be elucidated.<\/jats:p>","DOI":"10.1002\/ijc.30427","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T08:43:09Z","timestamp":1473669789000},"page":"34-40","source":"Crossref","is-referenced-by-count":6,"title":["Longitudinal fluctuation in mammographic percent density differentiates between interval and screen\u2010detected breast cancer"],"prefix":"10.1002","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-7086","authenticated-orcid":false,"given":"Fredrik","family":"Strand","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"},{"name":"Department of Diagnostic Radiology Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Humphreys","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"},{"name":"Swedish eScience Research Centre (SeRC) Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingmei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"},{"name":"Genome Institute of Singapore Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese M. 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