{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:57:40Z","timestamp":1789581460409,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,1,15]]},"abstract":"<jats:p>\n                    Complete Round 1 data (baseline and 12\u2010month follow\u2010up) for HPV FOCAL, a randomized trial establishing the efficacy of HPV DNA testing with cytology triage as a primary screen for cervical cancer are presented. Women were randomized to one of three arms: Control arm \u2013 Baseline liquid\u2010based cytology (LBC) with ASCUS results triaged with HPV testing; Intervention and Safety arms \u2013 Baseline HPV with LBC triage for HPV positives. Results are presented for 15,744 women allocated to the HPV (intervention and safety combined) and 9,408 to the control arms. For all age cohorts, the CIN3+ detection rate was higher in the HPV (7.5\/1,000; 95%CI: 6.2, 8.9) compared to the control arm (4.6\/1,000; 95%CI: 3.4, 6.2). The CIN2+ detection rates were also significantly higher in the HPV (16.5\/1,000; 95%CI: 14.6, 18.6)\n                    <jats:italic>vs<\/jats:italic>\n                    . the control arm (10.1\/1,000; 95%CI: 8.3, 12.4). In women \u226535 years, the overall detection rates for CIN2+ and CIN3+ were higher in the HPV\n                    <jats:italic>vs<\/jats:italic>\n                    . the control arm (CIN2+:10.0\/1,000\n                    <jats:italic>vs<\/jats:italic>\n                    . 5.2\/1,000; CIN3+: 4.2\/1,000\n                    <jats:italic>vs<\/jats:italic>\n                    . 2.2\/1,000 respectively, with a statistically significant difference for CIN2+). HPV testing detected significantly more CIN2+ in women 25\u201329 compared to LBC (63.7\/1,000; 95%CI: 51.9, 78.0\n                    <jats:italic>vs<\/jats:italic>\n                    . 32.4\/1,000; 95%CI: 22.3, 46.8). HPV testing resulted in significantly higher colposcopy referral rates for all age cohorts (HPV: 58.9\/1,000; 95%CI: 55.4, 62.7\n                    <jats:italic>vs<\/jats:italic>\n                    . control: 30.9\/1,000; 95%CI: 27.6, 34.6). At completion of Round 1 HPV\u2010based cervical cancer screening in a population\u2010based program resulted in greater CIN2+ detection of across all age cohorts compared to LBC screening.\n                  <\/jats:p>","DOI":"10.1002\/ijc.30454","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T13:41:58Z","timestamp":1475156518000},"page":"440-448","source":"Crossref","is-referenced-by-count":81,"title":["HPV for cervical cancer screening (HPV FOCAL): Complete Round 1 results of a randomized trial comparing HPV\u2010based primary screening to liquid\u2010based cytology for cervical cancer"],"prefix":"10.1002","volume":"140","author":[{"given":"Gina S.","family":"Ogilvie","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of British Columbia Vancouver BC Canada"},{"name":"British Columbia Centre for Disease Control Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mel","family":"Krajden","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia Vancouver BC Canada"},{"name":"British Columbia Centre for Disease Control Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"van Niekerk","sequence":"additional","affiliation":[{"name":"Lower Mainland Laboratories Vancouver BC Canada"},{"name":"Cervical cancer screening program, British Columbia Cancer Agency Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie W.","family":"Smith","sequence":"additional","affiliation":[{"name":"Cervical cancer screening program, British Columbia Cancer Agency Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrel","family":"Cook","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Disease Control Vancouver BC Canada"},{"name":"Cervical cancer screening program, British Columbia Cancer Agency Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Ceballos","sequence":"additional","affiliation":[{"name":"Cervical cancer screening program, British Columbia Cancer Agency Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marette","family":"Lee","sequence":"additional","affiliation":[{"name":"Cervical cancer screening program, British Columbia Cancer Agency Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gentile","sequence":"additional","affiliation":[{"name":"Cervical cancer screening program, British Columbia Cancer Agency Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lovedeep","family":"Gondara","sequence":"additional","affiliation":[{"name":"Cervical cancer screening program, British Columbia Cancer Agency Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Elwood\u2010Martin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Peacock","sequence":"additional","affiliation":[{"name":"Cervical cancer screening program, British Columbia Cancer Agency Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Stuart","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo L.","family":"Franco","sequence":"additional","affiliation":[{"name":"Departments of Oncology and Epidemiology &amp; Biostatistics, McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Coldman","sequence":"additional","affiliation":[{"name":"Cervical cancer screening program, British Columbia Cancer Agency Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"International Agency for Research on Cancer (IARC).World Health Organization. Globocan2012. Estimated cancer incidence mortality and prevalence worldwide 2012. Cervical cancer fact sheet. Retrieved 18 Jan 2016 from:http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_cancer.aspx"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.04.024"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16674-9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm4040614"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71191-X"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.108"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3728"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.10.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.11.020"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.11.076"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62218-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70156-1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61450-0"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073204"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70360-2"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.12.002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.12.022"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.489"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-111"},{"key":"e_1_2_10_23_1","unstructured":"SmithL OgilvieG KrajdenM et al. Methodological quality control measures of a population\u2010based screening trial: HPV FOCAL. Presented at the 30th Annual International Papillomavirus Conference Lisbon Portugal September17\u201321 2015."},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.01.538"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPTGD94EVRSJCG"},{"key":"e_1_2_10_26_1","volume-title":"Cancer incidence in five continents, Vol. X (electronic version)","author":"Forman D","year":"2013"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmja1754"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.37"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.04.012"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.09.085"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/428779"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqv019"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.30454","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.30454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:20:04Z","timestamp":1696357204000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.30454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,20]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,1,15]]}},"alternative-id":["10.1002\/ijc.30454"],"URL":"https:\/\/doi.org\/10.1002\/ijc.30454","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,20]]}}}