{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:33Z","timestamp":1786977873864,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The United States National Institutes of Health","award":["R37 CA070867"],"award-info":[{"award-number":["R37 CA070867"]}]},{"name":"The United States National Institutes of Health","award":["UM1 CA182910"],"award-info":[{"award-number":["UM1 CA182910"]}]},{"name":"The United States National Institutes of Health","award":["UM1 CA173640"],"award-info":[{"award-number":["UM1 CA173640"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,1,15]]},"abstract":"<jats:p>\n                    The association of obesity on survival among patients with colorectal cancer (CRC) has not been well characterized. We investigated the association of prediagnostic body mass index (BMI)\/waist\u2013hip ratio (WHR) and total\/cause\u2010specific mortality in CRC patients. Our study included 1,452 patients who participated in two large cohort studies and were diagnosed with CRC during follow\u2010up period. Participants were measured for anthropometrics and interviewed to collect relevant information at baseline, prior to any cancer diagnosis. Data on site\u2010specific cancer incidence and cause\u2010specific mortality were obtained\n                    <jats:italic>via<\/jats:italic>\n                    in\u2010person surveys and annual record linkage with cancer and vital statistics registries. Cox proportional hazard models were used to evaluate the associations of BMI and WHR with survival. A total of 547 participants died during the follow\u2010up period, including 499 who died of CRC. Relative to normal BMI (18.5 to &lt;25.0 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ), obesity (BMI\u2009\u2265\u200930 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) was associated with increased mortality resulting from all causes [hazard ratio (HR)\u2009=\u20091.5, 95% confidence interval (CI): 1.1\u20132.1] and CRC (HR\u2009=\u20091.5, 95% CI: 1.1\u20132.1). Elevated risk of death was also found among underweight patients (BMI\u2009&lt;\u200918.5 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ), although not all risk estimates were statistically significant. Overweight BMI (25.0 to &lt;30.0 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) was not associated with risk of death among CRC patients, nor was WHR. In conclusion, prediagnostic BMI was associated with survival among CRC patients following a U\u2010shape pattern; obesity was associated with high mortality after CRC diagnosis. These findings provide support for maintaining healthy weight to improve the survival of CRC patients.\n                  <\/jats:p>","DOI":"10.1002\/ijc.30459","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T16:57:49Z","timestamp":1476291469000},"page":"292-301","source":"Crossref","is-referenced-by-count":27,"title":["Prediagnosis body mass index and waist\u2013hip circumference ratio in association with colorectal cancer survival"],"prefix":"10.1002","volume":"140","author":[{"given":"Nan","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt\u2010Ingram Cancer Center, Vanderbilt University School of Medicine Nashville TN"},{"name":"Department of General Surgery Tangdu Hospital, Fourth Military Medical University Xi'an People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil K.","family":"Khankari","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt\u2010Ingram Cancer Center, Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt\u2010Ingram Cancer Center, Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Lan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt\u2010Ingram Cancer Center, Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Tang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Bing","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ou","family":"Shu","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt\u2010Ingram Cancer Center, Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1226-070X","authenticated-orcid":false,"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt\u2010Ingram Cancer Center, Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.29005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61649-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62038-9"},{"key":"e_1_2_6_5_1","unstructured":"American Institute for Cancer Research World Cancer Research Fund eds. 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