{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:39:55Z","timestamp":1784335195239,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The National Cancer Institute at the National Institutes of Health","award":["UM1 CA167552, R01 CA166150 and R01 CA149445"],"award-info":[{"award-number":["UM1 CA167552, R01 CA166150 and R01 CA149445"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Periodontal disease is a chronic inflammatory condition that has been associated with chronic diseases, including cancer. In an earlier prospective cohort analysis within the Health Professionals Follow\u2010Up Study (HPFS), we observed a 31% higher risk of non\u2010Hodgkin lymphoma (NHL) among participants with severe periodontal disease at baseline. Here, we extend the study with an additional 8 years of follow\u2010up, and conduct analyses with updated periodontal disease status and NHL subtypes. The HPFS is an ongoing prospective cohort study of 51,529 men in the USA Between baseline in 1986 and 2012, 875 cases of NHL were diagnosed, including 290 chronic lymphocytic leukemia\/small lymphocytic lymphomas (CLL\/SLL), 85 diffuse large B\u2010cell lymphomas and 91 follicular lymphomas. We performed multivariable Cox proportional hazards regression to evaluate associations of interest. History of periodontal disease at baseline was positively associated with risk of NHL overall (hazard ratio (HR)\u2009=\u20091.26, 95% confidence interval (CI): 1.06\u20131.49) and CLL\/SLL (HR\u2009=\u20091.41, 95% CI: 1.04\u20131.90). With updated periodontal status, HRs were 1.30 (95% CI: 1.11\u20131.51) for NHL overall and 1.41 (95% CI: 1.08\u20131.84) for CLL\/SLL. In contrast, after adjusting for periodontal disease, tooth loss was inversely associated with NHL, suggesting that other causes or consequences of tooth loss may have different implications for NHL etiology. Our findings suggest that periodontal disease is a risk factor for NHL. Whether periodontal disease is a direct or indirect cause of NHL, or is a marker of underlying systemic inflammation and\/or immune dysregulation, warrants further investigation.<\/jats:p>","DOI":"10.1002\/ijc.30518","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T19:23:11Z","timestamp":1479324191000},"page":"1020-1026","source":"Crossref","is-referenced-by-count":30,"title":["Periodontal disease and risk of non\u2010Hodgkin lymphoma in the Health Professionals Follow\u2010Up Study"],"prefix":"10.1002","volume":"140","author":[{"given":"Kimberly A.","family":"Bertrand","sequence":"first","affiliation":[{"name":"Slone Epidemiology Center at Boston University Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janki","family":"Shingala","sequence":"additional","affiliation":[{"name":"Tufts University Medford MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Evens","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Tufts Medical Center Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda M.","family":"Birmann","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Giovannucci","sequence":"additional","affiliation":[{"name":"Departments of Nutrition and Epidemiology Harvard T.H. Chan School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique S.","family":"Michaud","sequence":"additional","affiliation":[{"name":"Department of Public Health and Community Medicine Tufts University School of Medicine Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01811.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00972.x"},{"key":"e_1_2_8_4_1","first-page":"207","article-title":"Tooth loss in periodontal patients","volume":"67","author":"Matthews DC","year":"2001","journal-title":"J Can Dent 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