{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:22Z","timestamp":1786977922468,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T00:00:00Z","timestamp":1484697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>\n                    It is universally accepted that high\u2010risk human papillomavirus (HR\u2010HPV) is the cause of cervical dysplasia and cancer. More recently, it has been shown that HPV is also a marker of clinical outcome in oropharyngeal cancer. However, contemporary information is lacking on both the prevalence of HPV infection in vulvar cancer (VSCC), its precursor lesion, vulvar intraepithelial neoplasia (VIN) and the influence of HPV\u2010status on the prognosis of this malignancy. We have conducted a detailed population\u2010based study to examine rates of progression of VIN to VSCC, type\u2010specific HPV prevalence in vulvar disease and the influence of HPV status on clinical outcome in VSCC. We observed that the age at which women are diagnosed with VSCC is falling and there is a significant time gap between first diagnosis of VIN and progression to invasive disease. HR\u2010HPV infection was detected in 87% (97\/112) cases of VIN and 52% cases (32\/62) of VSCC. The presence of HR\u2010HPV in squamous intraepithelial lesion was associated with lower rates of progression to invasive cancer (hazard ratio, 0.22,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). In the adjusted analysis, HR\u2010HPV was associated with improved progression\u2010free survival of VSCC compared to those with HPV negative tumours (hazard ratio, 0.32,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02).\n                  <\/jats:p>","DOI":"10.1002\/ijc.30523","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T18:29:44Z","timestamp":1479320984000},"page":"1134-1146","source":"Crossref","is-referenced-by-count":60,"title":["HPV status and favourable outcome in vulvar squamous cancer"],"prefix":"10.1002","volume":"140","author":[{"given":"Katie","family":"Wakeham","sequence":"first","affiliation":[{"name":"Sussex Cancer Centre, Brighton and Sussex University Hospital"},{"name":"Institute of Cancer Sciences, University of Glasgow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics University of Strathclyde"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Cuschieri","sequence":"additional","affiliation":[{"name":"Scottish HPV Reference Laboratory Royal Infirmary of Edinburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Millan","sequence":"additional","affiliation":[{"name":"Department of Pathology The Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Vaccine Preventable Diseases Health Protection Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Pathology The Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Burton","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology Glasgow Royal Infirmary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S","family":"Reed","sequence":"additional","affiliation":[{"name":"Beatson West of Scotland Cancer Centre Glasgow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila V","family":"Graham","sequence":"additional","affiliation":[{"name":"MRC\u2010University of Glasgow Centre for Virus Research, University of Glasgow"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70137-7"},{"key":"e_1_2_7_3_1","unstructured":"ISD Scotland. 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