{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:17:12Z","timestamp":1790201832061,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T00:00:00Z","timestamp":1484697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Institute at the National Institutes of Health","award":["RC2 CA148576"],"award-info":[{"award-number":["RC2 CA148576"]}]},{"name":"The seventh framework program of DG Research of the European Commission, through the COHEAHR Network","award":["Grant nubmber: 603019"],"award-info":[{"award-number":["Grant nubmber: 603019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>We studied harms related to cervical cancer screening and management of screen\u2010positive women in the United States (US) and the Netherlands. We utilized data from four US integrated health care systems (SEARCH), the US National Health Interview Survey, New Mexico state, the Netherlands national histopathology registry, and included studies on adverse health effects of cervical screening. We compared the number of Papanicolaou (Pap) smear tests, abnormal test results, punch biopsies, treatments, health problems (anxiety, pain, bleeding and discharge) and preterm births associated with excisional treatments. Results were age\u2010standardized to the 2007 US population. Based on SEARCH, an estimated 36 million Pap tests were performed in 2007 for 91 million US women aged 21\u201365 years, leading to 2.3 million abnormal Pap tests, 1.5 million punch biopsies, 0.3 million treatments for precancerous lesions, 5 thousand preterm births and over 8 million health problems. Under the Netherlands screening practice, fewer Pap tests (58%), abnormal test results (64%), punch biopsies (75%), treatment procedures (40%), preterm births (60%) and health problems (63%) would have occurred. The SEARCH data did not differ much from other US data for 2007 or from more recent data up to 2013. Thus compared to the less intensive screening practice in the Netherlands, US practice of cervical cancer screening may have resulted in two\u2010 to threefold higher harms, while the effects on cervical cancer incidence and mortality are similar. The results are also of high relevance in making recommendations for HPV screening. Systematic collection of harms data is needed for monitoring and for better incorporation of harms in making screening recommendations.<\/jats:p>","DOI":"10.1002\/ijc.30524","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T18:28:34Z","timestamp":1479320914000},"page":"1215-1222","source":"Crossref","is-referenced-by-count":55,"title":["Harms of cervical cancer screening in the United States and the Netherlands"],"prefix":"10.1002","volume":"140","author":[{"given":"Dik","family":"Habbema","sequence":"first","affiliation":[{"name":"Department of Public Health Erasmus MC University Medical Center, Rotterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Weinmann","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northwest Center for Health Research Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Arbyn","sequence":"additional","affiliation":[{"name":"Unit of Cancer Epidemiology Belgian Cancer Centre, Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Kamineni","sequence":"additional","affiliation":[{"name":"Group Health Research Institute Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Williams","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research and Evaluation Maine Medical Center Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"M.C.M. de Kok","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus MC University Medical Center, Rotterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folkert","family":"van Kemenade","sequence":"additional","affiliation":[{"name":"Department of Pathology Erasmus MC University Medical Center, Rotterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry S.","family":"Field","sequence":"additional","affiliation":[{"name":"Meyers Primary Care Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"van Rosmalen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Erasmus MC University Medical Center, Rotterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Health Economics Consultant"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,18]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1:1247","article-title":"Trends in mortality from cervical cancer in the Nordic countries: association with organised screening programmes","author":"Laara E","year":"1987","journal-title":"Lancet"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6548.659"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.2003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02263.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03344.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1284"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68181-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5334"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6501"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f7668"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7773"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.6016"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.9967"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-0009.2011.00652.x"},{"key":"e_1_2_6_16_1","unstructured":"BuistDS TuzzioL GreenleeRT et al. 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