{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:17:46Z","timestamp":1791915466629,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T00:00:00Z","timestamp":1484697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Supported by the Swedish Research Council and by the Nordic Academy for Advanced Studies (NIASC Nordic Centre of Excellence in health-related eScience)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Immunosuppression involves an inability to control virus infections and increased incidence of virus\u2010associated cancers. Some cancers without known viral etiology are also increased, but data on exactly which cancer forms are increased has been inconsistent. To provide a reliable and generalizable estimate, with high statistical power and long follow\u2010up time, we assessed cancer risks using comprehensive, population\u2010based registries in two different countries and from two different immunosuppressed patient groups (solid organ transplant recipients (OTRs) and long\u2010term dialysis patients (LDPs)). National registries in Denmark and Sweden identified 20,804 OTRs and 31,140 LDPs that were followed up using national cancer registries. Standardized incidence ratios (SIR) compared to the general population were estimated. We found highly similar results, both for the two different countries and for the two different immunosuppressed cohorts, namely an increased incidence for the following specific cancer forms: Non\u2010melanoma skin cancer (NMSC), non\u2010Hodgkin's lymphoma and cancers of the lip, kidney, larynx and thyroid. The SIR for overall cancer among OTRs was 3.5 [<jats:italic>n<\/jats:italic>\u2009=\u20092,142, 95% CI, 3.4\u20133.7] in Sweden, 2.9 [<jats:italic>n<\/jats:italic>\u2009=\u20091,110, 95% CI, 2.8\u20133.1] in Denmark and 1.6 [<jats:italic>n<\/jats:italic>\u2009=\u20091,713, 95% CI, 1.5\u20131.6] among LDP. The SIR for NMSC among OTRs was 44.7 [<jats:italic>n<\/jats:italic>\u2009=\u2009994, 95% CI, 42\u201347.5] in Sweden and 41.5 [<jats:italic>n<\/jats:italic>\u2009=\u2009445, 95% CI, 37.8\u201345.5] in Denmark. The increased SIR for NMSC among LDPs was 5.3 [<jats:italic>n<\/jats:italic>\u2009=\u2009304, 95% CI, 4.7\u20135.9]). In summary, an increased SIR for a specific, similar set of cancer forms is consistently found among the immunosuppressed. Conceivable explanations include surveillance bias and immunosuppression\u2010related susceptibility to viral infections.<\/jats:p>","DOI":"10.1002\/ijc.30531","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T17:57:14Z","timestamp":1479751034000},"page":"1091-1101","source":"Crossref","is-referenced-by-count":75,"title":["Cancer risks after solid organ transplantation and after long\u2010term dialysis"],"prefix":"10.1002","volume":"140","author":[{"given":"Maria","family":"Hortlund","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila Sara","family":"Arroyo M\u00fchr","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Storm","sequence":"additional","affiliation":[{"name":"Department of Prevention &amp; Documentation Danish Cancer Society Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerda","family":"Engholm","sequence":"additional","affiliation":[{"name":"Department of Prevention &amp; Documentation Danish Cancer Society Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joakim","family":"Dillner","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davit","family":"Bzhalava","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24439"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24801"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi123"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61050-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2000.03703.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.125579"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.07021.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199003000-00006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.062"},{"key":"e_1_2_6_11_1","first-page":"101","article-title":"The risk of ano\u2010genital malignancies in dialysis and transplant patients","volume":"41","author":"Fairley CK","year":"1994","journal-title":"Clin Nephrol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)06154-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114668"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02298-4"},{"key":"e_1_2_6_15_1","unstructured":"The National Institute for Health and Welfare. 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