{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:38:21Z","timestamp":1788248301630,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T00:00:00Z","timestamp":1485475200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T00:00:00Z","timestamp":1485475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01-CA167421"],"award-info":[{"award-number":["R01-CA167421"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Foundation Graduate Research Fellowship","award":["DFG1106401"],"award-info":[{"award-number":["DFG1106401"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Cancer"],"published-print":{"date-parts":[[2017,3,15]]},"DOI":"10.1002\/ijc.30539","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T11:43:04Z","timestamp":1479987784000},"page":"1447-1456","source":"Crossref","is-referenced-by-count":23,"title":["Feasibility of clinical detection of cervical dysplasia using angle-resolved low coherence interferometry measurements of depth-resolved nuclear morphology"],"prefix":"10.1002","volume":"140","author":[{"given":"Derek","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering; Duke University; Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler K.","family":"Drake","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering; Duke University; Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen K.","family":"Smith-McCune","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences; University of California, San Francisco; San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa M.","family":"Darragh","sequence":"additional","affiliation":[{"name":"Department of Pathology; University of California, San Francisco; San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loris Y.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Adolescent Medicine; University of California, San Francisco; San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Wax","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering; Duke University; Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,27]]},"reference":[{"key":"10.1002\/ijc.30539-BIB0001|ijc30539-cit-0001","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"10.1002\/ijc.30539-BIB0002|ijc30539-cit-0002","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1097\/AOG.0b013e3182883a34","article-title":"2012 Updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors","volume":"121","author":"Massad","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1002\/ijc.30539-BIB0003|ijc30539-cit-0003","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/ijc.21955","article-title":"Overview of the European and North American studies on HPV testing in primary cervical cancer screening","volume":"119","author":"Cuzick","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1002\/ijc.30539-BIB0004|ijc30539-cit-0004","first-page":"626","article-title":"Colposcopy for the diagnosis of squamous intraepithelial lesions: a meta-analysis","volume":"91","author":"Mitchell","year":"1998","journal-title":"Obstet Gynecol"},{"key":"10.1002\/ijc.30539-BIB0005|ijc30539-cit-0005","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ajog.2008.12.025","article-title":"Colposcopy to evaluate abnormal cervical cytology in 2008","volume":"200","author":"Chase","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1002\/ijc.30539-BIB0006|ijc30539-cit-0006","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1001\/jama.285.11.1500","article-title":"Interobserver reproducibility of cervical cytologic and histologic interpretations - Realistic estimates from the ASCUS-LSIL triage study","volume":"285","author":"Stoler","year":"2001","journal-title":"JAMA"},{"key":"10.1002\/ijc.30539-BIB0007|ijc30539-cit-0007","first-page":"1006","article-title":"Observer variability in the scoring of colpophotographs","volume":"76","author":"Sellors","year":"1990","journal-title":"Obstet Gynecol"},{"key":"10.1002\/ijc.30539-BIB0008|ijc30539-cit-0008","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nrc2462","article-title":"Optical imaging for cervical cancer detection: solutions for a continuing global problem","volume":"8","author":"Thekkek","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1002\/ijc.30539-BIB0009|ijc30539-cit-0009","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00404-011-2009-4","article-title":"Recent advances in optical imaging for cervical cancer detection","volume":"284","author":"Orfanoudaki","year":"2011","journal-title":"Arch Gynecol Obstet"},{"key":"10.1002\/ijc.30539-BIB0010|ijc30539-cit-0010","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/infdis\/jis398","article-title":"Active squamous metaplasia of the cervical epithelium is associated with subsequent acquisition of human papillomavirus 16 infection among healthy young women","volume":"206","author":"Hwang","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1002\/ijc.30539-BIB0011|ijc30539-cit-0011","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/S0959-8049(02)00462-8","article-title":"New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections","volume":"38","author":"Doeberitz","year":"2002","journal-title":"Eur J Cancer"},{"key":"10.1002\/ijc.30539-BIB0012|ijc30539-cit-0012","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/PGP.0b013e31826916c7","article-title":"The lower anogenital squamous terminology standardization project for HPV-associated lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical","volume":"32","author":"Darragh","year":"2013","journal-title":"Pathol Int J Gynecol Pathol"},{"key":"10.1002\/ijc.30539-BIB0013|ijc30539-cit-0013","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1562\/0031-8655(2001)0730636AMOFCT2.0.CO2","article-title":"Autofluorescence microscopy of fresh cervical-tissue sections reveals alterations in tissue biochemistry with dysplasia","volume":"73","author":"Drezek","year":"2001","journal-title":"Photochem Photobiol"},{"key":"10.1002\/ijc.30539-BIB0014|ijc30539-cit-0014","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1562\/0031-8655(2003)077<0550:MABOON>2.0.CO;2","article-title":"Microanatomical and biochemical origins of normal and precancerous cervical autofluorescence using laser-scanning fluorescence confocal microscopy","volume":"77","author":"Pavlova","year":"2003","journal-title":"Photochem Photobiol"},{"key":"10.1002\/ijc.30539-BIB0015|ijc30539-cit-0015","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/j.1471-0528.2002.01311.x","article-title":"Autofluorescence spectroscopy for the diagnosis of cervical intraepithelial neoplasia","volume":"109","author":"Weingandt","year":"2002","journal-title":"BJOG Int J Obstet Gynecol"},{"key":"10.1002\/ijc.30539-BIB0016|ijc30539-cit-0016","doi-asserted-by":"crossref","DOI":"10.1117\/1.1899686","article-title":"Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer","volume":"10","author":"Chang","year":"2005","journal-title":"J Biomed Opt"},{"key":"10.1002\/ijc.30539-BIB0017|ijc30539-cit-0017","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/lsm.1097","article-title":"Identification of cervical intraepithelial neoplasia (CIN) using UV-excited fluorescence and diffuse-reflectance tissue spectroscopy","volume":"29","author":"Nordstrom","year":"2001","journal-title":"Laser Surg Med"},{"key":"10.1002\/ijc.30539-BIB0018|ijc30539-cit-0018","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/gyno.1994.1007","article-title":"Fluorescence spectroscopy - a diagnostic-tool for cervical intraepithelial neoplasia (cin)","volume":"52","author":"Ramanujam","year":"1994","journal-title":"Gynecol Oncol"},{"key":"10.1002\/ijc.30539-BIB0019|ijc30539-cit-0019","first-page":"682","article-title":"NAD(P)H and collagen as in vivo quantitative fluorescent biomarkers of epithelial precancerous changes","volume":"62","author":"Georgakoudi","year":"2002","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.30539-BIB0020|ijc30539-cit-0020","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1067\/mob.2002.121075","article-title":"Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo","volume":"186","author":"Georgakoudi","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1002\/ijc.30539-BIB0021|ijc30539-cit-0021","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1002\/ijc.23046","article-title":"Early detection of cervical neoplasia by Raman spectroscopy","volume":"121","author":"Jess","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1002\/ijc.30539-BIB0022|ijc30539-cit-0022","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1751-1097.1998.tb03262.x","article-title":"Near-infrared Raman spectroscopy for in vitro detection of cervical precancers","volume":"68","author":"Mahadevan-Jansen","year":"1998","journal-title":"Photochem Photobiol"},{"key":"10.1002\/ijc.30539-BIB0023|ijc30539-cit-0023","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1366\/0003702011953018","article-title":"Near-infrared Raman spectroscopy for in vivo detection of cervical precancers","volume":"55","author":"Utzinger","year":"2001","journal-title":"Appl Spectrosc"},{"key":"10.1002\/ijc.30539-BIB0024|ijc30539-cit-0024","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1048-891x.2004.14307.x","article-title":"Diagnostic efficacy of optical coherence tomography in the management of preinvasive and invasive cancer of uterine cervix and vulva","volume":"14","author":"Escobar","year":"2004","journal-title":"Int J Gynecol Cancer"},{"key":"10.1002\/ijc.30539-BIB0025|ijc30539-cit-0025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ajog.2004.11.054","article-title":"Optical coherence tomography: a pilot study of a new imaging technique for noninvasive examination of cervical tissue","volume":"193","author":"Zuluaga","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1002\/ijc.30539-BIB0026|ijc30539-cit-0026","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S1076-6332(03)80326-4","article-title":"Near real time confocal microscopy of amelanotic tissue: detection of dysplasia in ex-vivo cervical tissue","volume":"9","author":"Collier","year":"2002","journal-title":"Acad Radiol"},{"key":"10.1002\/ijc.30539-BIB0027|ijc30539-cit-0027","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/j.ygyno.2005.07.049","article-title":"Confocal microscopy: imaging cervical precancerous lesions","volume":"99","author":"Carlson","year":"2005","journal-title":"Gynecol Oncol"},{"key":"10.1002\/ijc.30539-BIB0028|ijc30539-cit-0028","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1111\/j.1471-0528.2009.02261.x","article-title":"Detection of cervical intraepithelial neoplasia in vivo using confocal endomicroscopy","volume":"116","author":"Tan","year":"2009","journal-title":"BJOG Int J Obstet Gynecol"},{"key":"10.1002\/ijc.30539-BIB0029|ijc30539-cit-0029","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.nano.2015.04.012","article-title":"Towards early detection of cervical cancer: Fractal dimension of AFM images of human cervical epithelial cells at different stages of progression to cancer","volume":"11","author":"Guz","year":"2015","journal-title":"Nanomed Nanotechnol"},{"key":"10.1002\/ijc.30539-BIB0030|ijc30539-cit-0030","doi-asserted-by":"crossref","first-page":"e0135869","DOI":"10.1371\/journal.pone.0135869","article-title":"Design of a novel low cost point of care tampon (POCkeT) colposcope for use in resource limited settings","volume":"10","author":"Lam","year":"2015","journal-title":"PLos One"},{"key":"10.1002\/ijc.30539-BIB0031|ijc30539-cit-0031","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1364\/BOE.6.000135","article-title":"Detection of cervical cancer based on photoacoustic imaging-the in-vitro results","volume":"6","author":"Peng","year":"2015","journal-title":"Biomed Opt Expr"},{"key":"10.1002\/ijc.30539-BIB0032|ijc30539-cit-0032","doi-asserted-by":"crossref","first-page":"e0125706","DOI":"10.1371\/journal.pone.0125706","article-title":"Enhancement of early cervical cancer diagnosis with epithelial layer analysis of fluorescence lifetime images","volume":"10","author":"Gu","year":"2015","journal-title":"PLoS One"},{"key":"10.1002\/ijc.30539-BIB0033|ijc30539-cit-0033","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1364\/BOE.6.000870","article-title":"Optimizing modulation frequency for structured illumination in a fiber-optic microendoscope to image nuclear morphometry in columnar epithelium","volume":"6","author":"Keahey","year":"2015","journal-title":"Biomed Opt Expr"},{"key":"10.1002\/ijc.30539-BIB0034|ijc30539-cit-0034","first-page":"1651","article-title":"Natural-history of intraepithelial neoplasia in humans with implications for cancer chemoprevention strategy","volume":"52","author":"Boone","year":"1992","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.30539-BIB0035|ijc30539-cit-0035","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/dc.21234","article-title":"Cancer nucleus: morphology and beyond","volume":"38","author":"Dey","year":"2010","journal-title":"Diagn Cytopathol"},{"key":"10.1002\/ijc.30539-BIB0036|ijc30539-cit-0036","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1158\/1940-6207.CAPR-12-0221","article-title":"A pilot study of low-cost, high-resolution microendoscopy as a tool for identifying women with cervical precancer","volume":"5","author":"Pierce","year":"2012","journal-title":"Cancer Prev Res"},{"key":"10.1002\/ijc.30539-BIB0037|ijc30539-cit-0037","doi-asserted-by":"crossref","first-page":"e44924","DOI":"10.1371\/journal.pone.0044924","article-title":"High-resolution microendoscopy for the detection of cervical neoplasia in low-resource settings","volume":"7","author":"Quinn","year":"2012","journal-title":"PLoS One"},{"key":"10.1002\/ijc.30539-BIB0038|ijc30539-cit-0038","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1364\/OE.11.003171","article-title":"Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo","volume":"11","author":"Sung","year":"2003","journal-title":"Opt Expr"},{"key":"10.1002\/ijc.30539-BIB0039|ijc30539-cit-0039","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1103\/PhysRevC.59.1290","article-title":"Elastic scattering of pions from the three-nucleon system","volume":"59","author":"Collier","year":"1999","journal-title":"Phys Rev C"},{"key":"10.1002\/ijc.30539-BIB0040|ijc30539-cit-0040","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1117\/1.1528950","article-title":"Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture","volume":"8","author":"Drezek","year":"2003","journal-title":"J Biomed Opt"},{"key":"10.1002\/ijc.30539-BIB0041|ijc30539-cit-0041","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1053\/j.gastro.2010.09.008","article-title":"Detection of dysplasia in Barrett's esophagus with in vivo depth-resolved nuclear morphology measurements","volume":"140","author":"Terry","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1002\/ijc.30539-BIB0042|ijc30539-cit-0042","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1364\/BOE.6.002755","article-title":"Evaluation of hybrid algorithm for analysis of scattered light using ex vivo nuclear morphology measurements of cervical epithelium","volume":"6","author":"Ho","year":"2015","journal-title":"Biomed Opt Expr"},{"key":"10.1002\/ijc.30539-BIB0043|ijc30539-cit-0043","doi-asserted-by":"crossref","first-page":"106002","DOI":"10.1117\/1.3631799","article-title":"Detection of intestinal dysplasia using angle-resolved low coherence interferometry","volume":"16","author":"Terry","year":"2011","journal-title":"J Biomed Opt"},{"key":"10.1002\/ijc.30539-BIB0044|ijc30539-cit-0044","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1109\/JSTQE.2007.913969","article-title":"Review and recent development of angle-resolved low-coherence interferometry for detection of precancerous cells in human esophageal epithelium","volume":"14","author":"Brown","year":"2008","journal-title":"IEEE J Sel Top Quant"},{"key":"10.1002\/ijc.30539-BIB0045|ijc30539-cit-0045","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1364\/BOE.5.003292","article-title":"Wavelet transform fast inverse light scattering analysis for size determination of spherical scatterers","volume":"5","author":"Ho","year":"2014","journal-title":"Biomed Opt Expr"},{"key":"10.1002\/ijc.30539-BIB0046|ijc30539-cit-0046","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/S0140-6736(04)17354-6","article-title":"Regression of low-grade squamous intra-epithelial lesions in young women","volume":"364","author":"Moscicki","year":"2004","journal-title":"Lancet"},{"key":"10.1002\/ijc.30539-BIB0047|ijc30539-cit-0047","doi-asserted-by":"crossref","first-page":"011003","DOI":"10.1117\/1.3520130","article-title":"Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology","volume":"16","author":"Zhu","year":"2011","journal-title":"J Biomed Opt"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.30539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ijc.30539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T19:57:18Z","timestamp":1718913438000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.30539"}},"subtitle":["a\/LCI as a real-time optical biopsy system"],"short-title":[],"issued":{"date-parts":[[2017,1,27]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,3,15]]}},"URL":"https:\/\/doi.org\/10.1002\/ijc.30539","archive":["Portico"],"relation":{},"ISSN":["0020-7136"],"issn-type":[{"value":"0020-7136","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,27]]}}}