{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:35:45Z","timestamp":1791329745331,"version":"4.3.1"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:00:00Z","timestamp":1487808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pelotonia Idea Grant and philanthropic funding"},{"name":"NIH\/NCI T32"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,4,15]]},"abstract":"<jats:p>\n                    Epstein\u2010Barr virus (EBV)\u2010encoded RNAs (EBER) in tumor tissue and cell\u2010free plasma EBV\u2010DNA (pEBVd) are detected in EBV\u2010associated lymphomas. Studies have suggested that EBER+ peripheral T\u2010cell lymphomas (PTCL) have worse prognosis but the role of EBV in these neoplasms remains unclear. pEBVd is quantitative and more easily amenable to standardization than EBER, but frequency of pEBVd detection, clinical impact and agreement with EBER status in PTCL are unknown. We retrospectively assessed frequency of detectable pre\u2010treatment pEBVd, presence of EBER in tumor tissue, and outcomes in 61 of 135 EBV\u2010assessable PTCL patients. Fifteen of 61 patients (24.5%, 95% CI: 14\u201337%) were pre\u2010treatment pEBVd+, with no significant differences in baseline characteristics or treatment between pEBVd+ and pEBVd\u2212 patients. EBER\u2010ISH was performed on 10 pEBVd+ and 35 pEBVd\u2212 tumors. All 10 pEBVd+ patients were EBER+, but 9 pEBVd\u2212 patients were also EBER+. With median follow up of 24 months (range 1\u201396), overall survival (OS) was shorter in pEBVd+ compared to pEBVd\u2212 patients (13\n                    <jats:italic>vs<\/jats:italic>\n                    . 72 months;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). In our retrospective study, pre\u2010treatment pEBVd was elevated in 25% of PTCL patients, was highly specific for EBER+ tumors, and was associated with shorter survival. pEBVd should be further explored as a prognostic variable and tumor biomarker in PTCL.\n                  <\/jats:p>","DOI":"10.1002\/ijc.30566","type":"journal-article","created":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T18:19:49Z","timestamp":1481393989000},"page":"1899-1906","source":"Crossref","is-referenced-by-count":19,"title":["Frequency and clinical correlates of elevated plasma Epstein\u2010Barr virus DNA at diagnosis in peripheral T\u2010cell lymphomas"],"prefix":"10.1002","volume":"140","author":[{"given":"Bradley M.","family":"Haverkos","sequence":"first","affiliation":[{"name":"Division of Hematology University of Colorado Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Hematology The Ohio State University Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Gru","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Virginia Charlottesville VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Pancholi","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aharon G.","family":"Freud","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Columbus OH"},{"name":"Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Mishra","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Ruppert","sequence":"additional","affiliation":[{"name":"Division of Hematology The Ohio State University Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Baiocchi","sequence":"additional","affiliation":[{"name":"Division of Hematology The Ohio State University Columbus OH"},{"name":"Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Porcu","sequence":"additional","affiliation":[{"name":"Division of Hematology The Ohio State University Columbus OH"},{"name":"Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University Columbus 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