{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:28:47Z","timestamp":1790684927443,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008363","name":"Danish Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Burkitt lymphoma (BL) is a malignant disease, which is frequently found in areas with holoendemic <jats:italic>Plasmodium falciparum<\/jats:italic> malaria. We have previously found that the VAR2CSA protein is present on malaria\u2010infected erythrocytes and facilitates a highly specific binding to the placenta. ofCS is absent in other non\u2010malignant tissues and thus VAR2CSA generally facilitates parasite sequestration and accumulation in pregnant women. In this study, we show that the specific receptor for VAR2CSA, the oncofetal chondroitin sulfate (ofCS), is likewise present in BL tissue and cell lines. We therefore explored whether ofCS in BL could act as anchor site for VAR2CSA\u2010expressing infected erythrocytes. In contrast to the placenta, we found no evidence of <jats:italic>in vivo<\/jats:italic> sequestering of infected erythrocytes in the BL tissue. Furthermore, we found VAR2CSA\u2010specific antibody titers in children with endemic BL to be lower than in control children from the same malaria endemic region. The abundant presence of ofCS in BL tissue and the absence of ofCS in non\u2010malignant tissue encouraged us to examine whether recombinant VAR2CSA could be used to target BL. We confirmed the binding of VAR2CSA to BL\u2010derived cells and showed that a VAR2CSA drug conjugate efficiently killed the BL\u2010derived cell lines <jats:italic>in vitro<\/jats:italic>. These results identify ofCS as a novel therapeutic BL target and highlight how VAR2CSA could be used as a tool for the discovery of novel approaches for directing BL therapy.<\/jats:p>","DOI":"10.1002\/ijc.30575","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T17:49:37Z","timestamp":1482256177000},"page":"1597-1608","source":"Crossref","is-referenced-by-count":20,"title":["Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration"],"prefix":"10.1002","volume":"140","author":[{"given":"Mette \u00d8.","family":"Agerb\u00e6k","sequence":"first","affiliation":[{"name":"Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina 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