{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:38Z","timestamp":1786977938846,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Institute of the National Institutes of Health","award":["CA133569"],"award-info":[{"award-number":["CA133569"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,4,15]]},"abstract":"<jats:p>\n                    Studies of the clinical relevance of human papillomavirus (HPV) DNA load have focused mainly on HPV16 and HPV18. Data on other oncogenic types are rare. Study subjects were women enrolled in the atypical squamous cells of undetermined significance (ASC\u2010US) and low\u2010grade squamous intraepithelial lesion (LSIL) triage study who had \u22651 of 11 non\u2010HPV16\/18 oncogenic types detected during a 2\u2010year follow\u2010up at 6\u2010month intervals. Viral load measurements were performed on the first type\u2010specific HPV\u2010positive specimens. The association of cervical intraepithelial neoplasia grades 2\u20133 (CIN2\/3) with type\u2010specific HPV DNA load was assessed with discrete\u2010time Cox regression. Overall, the increase in the cumulative risk of CIN2\/3 per 1 unit increase in log\n                    <jats:sub>10<\/jats:sub>\n                    \u2010transformed viral load was statistically significant for four types within species 9 including HPV31 (adjusted hazard ratio [HR\n                    <jats:sub>adjusted<\/jats:sub>\n                    ]\u2009=\u20091.32: 95% confidence interval [CI], 1.14\u20131.52), HPV35 (HR\n                    <jats:sub>adjusted<\/jats:sub>\n                    \u2009=\u20091.47; 95% CI, 1.23\u20131.76), HPV52 (HR\n                    <jats:sub>adjusted<\/jats:sub>\n                    \u2009=\u20091.14; 95% CI, 1.01\u20131.30) and HPV58 (HR\n                    <jats:sub>adjusted<\/jats:sub>\n                    \u2009=\u20091.49; 95% CI, 1.23\u20131.82). The association was marginally significant for HPV33 (species 9) and HPV45 (species 7) and was not appreciable for other types. The per 1 log\n                    <jats:sub>10<\/jats:sub>\n                    \u2010unit increase in viral load of a group of species 9 non\u2010HPV16 oncogenic types was statistically significantly associated with risk of CIN2\/3 for women with a cytologic diagnosis of within normal limits, ASC\u2010US, or LSIL at the first HPV\u2010positive visit but not for those with high\u2010grade SIL. Findings suggest that the viral load\u2010associated risk of CIN2\/3 is type\u2010dependent, and mainly restricted to the species of HPV types related to HPV16, which shares this association.\n                  <\/jats:p>","DOI":"10.1002\/ijc.30594","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T17:50:45Z","timestamp":1483552245000},"page":"1747-1756","source":"Crossref","is-referenced-by-count":32,"title":["Type\u2010dependent association between risk of cervical intraepithelial neoplasia and viral load of oncogenic human papillomavirus types other than types 16 and 18"],"prefix":"10.1002","volume":"140","author":[{"given":"Long","family":"Fu Xi","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Medicine University of Washington Seattle WA"},{"name":"Department of Epidemiology University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Schiffman","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ke","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research Peking University School of Oncology Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health and Community Medicine University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise A.","family":"Galloway","sequence":"additional","affiliation":[{"name":"Division of Human Biology Fred Hutchinson Cancer Research Center Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghu","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research Peking University School of Oncology Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Hulbert","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Winer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Koutsky","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy B.","family":"Kiviat","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine University of Washington Seattle 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